Q06833 Nucleus-vacuole NVJ2 559292 None SL-0178 SL-0182 Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Single-pass type II membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000269|PubMed:22250200}; Single- pass type II membrane protein {ECO:0000305}. Note=Enriched at the nucleus-vacuole junction where it becomes increasingly concentrated as cells enter into the late-logarithmic growth phase (PubMed:22250200). During endoplasmic reticulum (ER) stress, localizes to ER-Golgi contacts (PubMed:28011845). {ECO:0000269|PubMed:22250200, ECO:0000269|PubMed:28011845}. UNIPROT Q06833 UNIPROT D6W491 Pfam PF10296 Pfam PF00169 PROSITE PS51847 During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, induces contacts between the ER and medial- Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}. P39743 EBI-7295400 0.65 P43603 EBI-489033 0.00 Q02159 EBI-860443 0.00 P47068 EBI-7295421 0.44 P0CF34 EBI-7295458 0.44 P80667 EBI-7296890 0.44 P32790 EBI-7310006 0.31 P10591 EBI-3682273 0.35 P10592 EBI-3719222 0.35 P11484 EBI-3786837 0.35 P40150 EBI-3803850 0.35 GO:0071944 GO:0005783 GO:0005789 GO:0016021 GO:0031965 GO:0071561 GO:0008289 GO:0035621 Transmembrane UniProt Sequence Analysis {ECO:0000255} MASLKVFLAVYLLGGITFLPLVLFTLYKIHLLYSNLKSASKKELDHDTADEIDEKTRLLARDIDPEFKARKLEEQLGVKVFNKGWITVTKQYYYHSSEVAVILKNSNNNKDSDTALQEQILQRTDLKKKQRFFAVLRHGNLFLYKDDSQNANLVHAISLQNRFITIWPRFDELGKEELPDASLFTKRTCIAIFKNDLVSIDSKNHNVILPHFDPLTSAESNNGDISTNDTTHEYQSQFHSSNQFFLYFDNNMDKEDWYYQLINASKNSNSLSTGLLDPNVSANAAHLKTKDMLQLIQDINSTENQLTTKWLNALLGRLFLSLQQTDTLNKFIHEKICKKLNKIKTPGFLDDLVVEKVDVGDSAPLFTSPELLELSPEGSTKIAIDVQYRGNLTIIIATKASINLGSRFKQREVSLQLSIKIKEFSGPLLFLIKPPPSNRIWYAFRTEPIMDFEIEPIVSSSKLSYNVVTNAIKSKFAEAVKESLVVPFMDDIVFYPTPNEVYRGGIWEEQDPEAAARARTAAAASDMNNTSAKEHLEALQEGGMKTQSRIKKALRPERKKENLKDLVDASGVATKTTTQTTVTTATNDDVSSSENSTKSRKYFKNSIKKIGRWYKDNVGNSSDTEDMDEIDVQDKKNDDSADERESDNPILTSNPKMISNRRPVPRRPSQPLNTLSPKLEGRKEKDTENFPVPPSASNMNASKMFANKENRKFSVSSNDSQNSLKNGDPHVKASKLESSQAFVKKTSQNRFNDGFFKQDLEFEEQREPKL 770