Q08DP6 Rho ARHGAP10 9913 None SL-0198 Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Association to cell membrane is dependent on PH domain. {ECO:0000250}. UNIPROT Q08DP6 Pfam PF00169 Pfam PF00620 Pfam PF14604 PROSITE PS50003 PROSITE PS50238 PROSITE PS50002 GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). {ECO:0000250}. GO:0005829 GO:0048471 GO:0005886 GO:0005096 GO:0007010 GO:0043066 GO:0007165 Unknown UniProt Sequence Analysis MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKTLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETERNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPPPFGSSWVKHYCMYRKAAKKFTMIPFEHRSGGKLGDGEVFFLKECIRRHTDSIDRRFCFDVEAADRPGISLTMQAFSEEERKQWLEVLGGKEALFPSFNRAIIPRPEGSAQLDKMGFTILRKCIRAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSVDWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTPPDATLPEPGPLSAPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDRPSLPKEDTPPSSLDSLSSPSPTTATALGHPGPDRNHLLTDGGSFGDWAPTAPSQARSSAVQWLNPQSPTTPSCSPAVTPPSPKLPPVPLSLPATVADKPPESIISRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL 785