Q0VD51 E3 RNF13 9913 None SL-0178 SL-0179 SL-0182 Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:O54965}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000250|UniProtKB:O54965}; Single-pass type I membrane protein {ECO:0000255}. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. {ECO:0000250|UniProtKB:O54965}. UNIPROT Q0VD51 Pfam PF02225 Pfam PF13639 PROSITE PS50089 E3 ubiquitin-protein ligase that regulates cell proliferation. Involved in apoptosis regulation. Mediates ER stress- induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. Also involved in protein trafficking and localization. {ECO:0000250|UniProtKB:O43567}. GO:0005829 GO:0005783 GO:0005789 GO:0000139 GO:0016021 GO:0031902 GO:0005765 GO:0005637 GO:0005654 GO:0008432 GO:0046872 GO:0061630 GO:0004842 GO:0051640 GO:0070304 GO:0051865 GO:0006511 Transmembrane UniProt Sequence Analysis {ECO:0000255} MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVRDNSSGTFIVLIRRLDCNFDEKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTYEKGGHIILVPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENEVSEHTPLLRPLASASTQSFGALSESRSHQNMTESSDYEEDDNDTDSSDAENEINEHSVVVQLQPNGERDYNIANTV 380