Q3V0I2 Proline-rich Prr7 10090 None SL-0198 Cell membrane {ECO:0000250|UniProtKB:Q8TB68}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P0C6T3}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P0C6T3}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8TB68}. Synapse {ECO:0000250|UniProtKB:P0C6T3}. Cell projection, dendrite {ECO:0000250|UniProtKB:P0C6T3}. Nucleus {ECO:0000250|UniProtKB:P0C6T3}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Translocates from synapses to nuclei following NMDA receptor activity (By similarity). {ECO:0000250|UniProtKB:P0C6T3}. UNIPROT Q3V0I2 Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (By similarity). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:27657535). Might promote apoptosis in T cells (By similarity). {ECO:0000250|UniProtKB:P0C6T3, ECO:0000250|UniProtKB:Q8TB68, ECO:0000269|PubMed:27657535}. Q9QWI6 EBI-27100778 0.35 GO:0070161 GO:0005829 GO:0030425 GO:0098978 GO:0016021 GO:0043005 GO:0005654 GO:0005634 GO:0048471 GO:0005886 GO:0014069 GO:0098839 GO:0099092 GO:0045202 GO:0036041 GO:1990782 GO:0044877 GO:0044389 GO:0002250 GO:0046632 GO:0031397 GO:0043065 GO:0010942 GO:2001269 GO:0099527 GO:0033077 Transmembrane UniProt Sequence Analysis {ECO:0000255} MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPPPPHRSRLEAPVHAHSHVHVHPLLHHGPAPPHAHPHPHHHALPHPPPPHLAVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAAPCPALCLQAERSRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV 269