Q60664 Processed Irag2 10090 None SL-0178 [Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm {ECO:0000269|PubMed:8798562}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20071408}; Single-pass type IV membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000305|PubMed:29878215}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5RHB5}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q5RHB5}. Chromosome {ECO:0000250|UniProtKB:Q5RHB5}. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane. {ECO:0000269|PubMed:20071408}. UNIPROT Q60664 UNIPROT Q7TMU8 Pfam PF05781 Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion (PubMed:9314557). Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules (PubMed:29878215). {ECO:0000269|PubMed:29878215, ECO:0000269|PubMed:9314557}. A3KGF7 EBI-688126 0.37 P70227 EBI-9212709 0.27 Q63269 EBI-9212784 0.46 E9Q401 EBI-20567306 0.35 GO:0005694 GO:0005783 GO:0005789 GO:0030176 GO:0005815 GO:0005635 GO:0000922 GO:0008017 GO:0002376 GO:0006997 GO:0007338 Transmembrane UniProt Sequence Analysis {ECO:0000255} MLCVKGPPEQEPEDGALDVTRGCQCPLPTEDSILGQELLDCTRMNEDQSTDENGAGHFYSESPSQLREYLTQPSSEQTSSSESTVTSSESGSDILHMASGDLDCKPLCEKEEEARAASAMQGTSLAPAAYGDYTSVGVAKAASQLEAGEELRTTENGGKGSAPGETEISMPPKASVKLVNFQQSENTSANEKEVEAEFLRLSLGLKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPLCEEDNQAQEIVKKLEKSIVLLSQCTARVASRAEMLGAINQESRVSRAVEVMIQHVENLKRMYAKEHAELEDLKQALLQNDRSFNSLPDEDDCQIKKRSSSLNSKPSSLRRVTIASLPRNLGNVGLVSGMENNDRFSRRSSSWRILGTKQGEHRPSLHRFISTYSWADAEDERSDVKARDAPEPQGEEAVERTRKPSLSERRSSTLAWDRGTICSSVASWVTHLQASFRRANRALWLTGLIIILIAALMSFLTGQLFQTAVEAAPTQEGDSWLSLEHILWPFTRLGHDGPPPV 539