Q68FU1 Pleckstrin Plekhf1 10116 None SL-0198 Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Lysosome {ECO:0000250}. Note=Translocates to lysosome during apoptosis. {ECO:0000250}. UNIPROT Q68FU1 Pfam PF01363 Pfam PF00169 PROSITE PS50003 PROSITE PS50178 May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity). {ECO:0000250}. GO:0005769 GO:0005764 GO:0005634 GO:0048471 GO:0046872 GO:0035091 GO:0032266 GO:0070273 GO:0010314 GO:0006915 GO:0007032 GO:0008333 GO:0010508 GO:2001244 GO:0072659 GO:0016050 Unknown UniProt Sequence Analysis MVDHLANTEINSQRIAAVENCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYGSIVLSKRKYRSQHIIPLEEVTLEPLPETLQAKNRWMIKTAKKSFVVSAASTTERQEWISHIEECVRRQLLATGRQPTTEHAAPWIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCAECSRERFLLPRLSPKPLRVCSLCYRELAAQKRREEAKERFRGSPGQLTHLGSTMCGASSGDDDDSDEDREGSGDGDWPTQVEFYASGVSWSAFHS 279