Q90972 E3 RNF13 9031 None SL-0178 SL-0179 SL-0182 Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:O54965}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000305|PubMed:8610176}; Single-pass type I membrane protein {ECO:0000255}. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. {ECO:0000250|UniProtKB:O54965}. UNIPROT Q90972 UNIPROT Q533M4 Pfam PF02225 Pfam PF13639 PROSITE PS50089 E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:20015074). Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (By similarity). {ECO:0000250|UniProtKB:O43567, ECO:0000269|PubMed:20015074}. GO:0005829 GO:0005783 GO:0005789 GO:0016021 GO:0031902 GO:0005765 GO:0005654 GO:0008432 GO:0046872 GO:0061630 GO:0004842 GO:0051640 GO:0070304 GO:0051865 GO:0006511 Transmembrane UniProt Sequence Analysis {ECO:0000255} MLLSIGMLMLSATQIYTIVTVQLFAFLNLLPVEADILAYNFENGTQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIAPPPLRDNSSTAFIVLIRRLECNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEILKKIDIPSVFIGEASANSLKEEFTYEKGGHVVLIPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSETDSSQEENEVSENTPLLRPLASVSTQSFGALSESHSHQNMTESSEYEEDDNDNIDSSDAESGVNEESVVVQLQPNDERDYRVTNTV 381