Q96T37 RNA-binding RBM15 9606 None SL-0178 SL-0182 Nucleus speckle {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:24100041}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:24100041}. Nucleus envelope {ECO:0000269|PubMed:19586903}. Nucleus membrane {ECO:0000269|PubMed:19786495}; Peripheral membrane protein {ECO:0000269|PubMed:19786495}. Note=Colocalizes at the nuclear pore with DBP5 and NXF1. {ECO:0000269|PubMed:19786495}. UNIPROT Q96T37 UNIPROT A1A693 UNIPROT Q3ZB86 UNIPROT Q4V760 UNIPROT Q5D058 UNIPROT Q5T613 UNIPROT Q86VW9 UNIPROT Q96PE4 UNIPROT Q96SC5 UNIPROT Q96SC6 UNIPROT Q96SC9 UNIPROT Q96SD0 UNIPROT Q96T38 UNIPROT Q9BRA5 UNIPROT Q9H6R8 UNIPROT Q9H9Y0 Pfam PF00076 Pfam PF07744 PROSITE PS50102 PROSITE PS50917 OMIM 606077 DisGeNET 64783 RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. Note=A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene. {ECO:0000269|PubMed:11344311, ECO:0000269|PubMed:11431691}. Q13137 EBI-10293900 0.56 Q8NDT2 EBI-21889356 0.35 Q8NFQ8 EBI-21508086 0.35 O60346 EBI-2514920 0.54 Q13573 EBI-7950968 0.35 Q9H492 EBI-3044058 0.35 P45983 EBI-7235213 0.37 P78362 EBI-6658735 0.44 Q7TSJ6 EBI-8798662 0.27 Q8IVL1 EBI-10293910 0.56 Q92841 EBI-10293920 0.56 Q9BRK4 EBI-10293942 0.56 Q9C0F1 EBI-10293956 0.56 Q96L14 EBI-11022408 0.35 O60825 EBI-11070701 0.35 P01106 EBI-11105437 0.35 Q6PDM2 EBI-11155641 0.35 Q68CZ1 EBI-11368346 0.27 Q8N0Z3 EBI-11392023 0.27 Q9UJV9 EBI-11473486 0.35 Q9H2G4 EBI-24501963 0.56 Q8IZP0 EBI-24422299 0.56 I6T1Z2 EBI-12581451 0.35 Q9NZQ3 EBI-21676174 0.35 Q8N307 EBI-21729950 0.35 Q86VM9 EBI-21769401 0.35 P40967 EBI-21773380 0.35 Q86U44 EBI-20594935 0.35 Q15007 EBI-20595349 0.35 Q12824 EBI-20624550 0.27 Q09666 EBI-20913094 0.40 A2A935 EBI-21022882 0.35 P14404 EBI-21026252 0.35 Q9ULK4 EBI-25472850 0.35 Q09161 EBI-26396507 0.35 Q53F19 EBI-26396827 0.35 P48431 EBI-26574478 0.35 P07947 EBI-30849745 0.44 P30530 EBI-32719959 0.27 P22607 EBI-32721979 0.27 P35968 EBI-32723270 0.27 Q12866 EBI-32723870 0.27 GO:0031965 GO:0016607 GO:0005654 GO:0005634 GO:0036396 GO:0003729 GO:0003723 GO:0001569 GO:0009048 GO:0045638 GO:0060674 GO:0007221 GO:0000381 GO:0045652 GO:0001510 GO:0048536 GO:0038163 GO:0060412 Peripheral UniProt Experimental Evidence {ECO:0000269|PubMed:19786495} MRTAGRDPVPRRSPRWRRAVPLCETSAGRRVTQLRGDDLRRPATMKGKERSPVKAKRSRGGEDSTSRGERSKKLGGSGGSNGSSSGKTDSGGGSRRSLHLDKSSSRGGSREYDTGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDGAEYKTLKISELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDTYPPSASVVGASVGGHRHPPGGGGGQRSLSPGGAALGYRDYRLQQLALGRLPPPPPPPLPRDLERERDYPFYERVRPAYSLEPRVGAGAGAAPFREVDEISPEDDQRANRTLFLGNLDITVTESDLRRAFDRFGVITEVDIKRPSRGQTSTYGFLKFENLDMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGTIRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQYLQPLPLTHYELVTDAFGHRAPDPLRGARDRTPPLLYRDRDRDLYPDSDWVPPPPPVRERSTRTAATSVPAYEPLDSLDRRRDGWSLDRDRGDRDLPSSRDQPRKRRLPEESGGRHLDRSPESDRPRKRHCAPSPDRSPELSSSRDRYNSDNDRSSRLLLERPSPIRDRRGSLEKSQGDKRDRKNSASAERDRKHRTTAPTEGKSPLKKEDRSDGSAPSTSTASSKLKSPSQKQDGGTAPVASASPKLCLAWQGMLLLKNSNFPSNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQRLRLDQPKLDEVTRRIKVAGPNGYAILLAVPGSSDSRSSSSSAASDTATSTQRPLRNLVSYLKQKQAAGVISLPVGGNKDKENTGVLHAFPPCEFSQQFLDSPAKALAKSEEDYLVMIIVRGFGFQIGVRYENKKRENLALTLL 977