Q9DBS1 Transmembrane Tmem43 10090 None SL-0178 SL-0179 SL-0182 Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BTV4}. Nucleus inner membrane {ECO:0000269|PubMed:18230648}; Multi-pass membrane protein. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen. {ECO:0000269|PubMed:18230648}. UNIPROT Q9DBS1 Pfam PF07787 May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (PubMed:18230648). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF- kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity). {ECO:0000250|UniProtKB:Q9BTV4, ECO:0000269|PubMed:18230648}. P68510 EBI-8586548 0.35 Q8BP00 EBI-4283417 0.35 GO:0005788 GO:0005789 GO:0005794 GO:0005639 GO:0005637 GO:0042802 GO:0043621 GO:0045087 GO:0071763 Transmembrane UniProt Sequence Analysis {ECO:0000255} MAANYSSTSSRKEHVKVTSEPQPGFLERLSETSGGMFVGLMTFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESSEYTEDGQVKKETKYSYNTEWRSEIVNSRNFDREIGHKNPSAMAVESFTATAPFVQIGRFFLSAGLIDKIDNFKALSLAKLEDPHVDIIRRGDFFYHSENPKYPEVGDVRVSFSYAGLSSDDPDLGPAHVVTVIARQRGDQLIPYSTKSGDTLLLLHHGDFSAEEVFRREQKSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWAALIGCLALVPIIIARTRVPAKKLE 400