Q9H7Z7 Prostaglandin PTGES2 9606 None SL-0198 Golgi apparatus membrane {ECO:0000269|PubMed:12835322}; Single-pass membrane protein {ECO:0000255}. [Prostaglandin E synthase 2 truncated form]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12835322}. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region. {ECO:0000269|PubMed:12835322}. UNIPROT Q9H7Z7 UNIPROT Q53EW9 UNIPROT Q5SYV6 UNIPROT Q96GI0 UNIPROT Q96GL2 Pfam PF13417 PROSITE PS00195 PROSITE PS51354 PROSITE PS50405 OMIM 608152 DisGeNET 80142 Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:18198127, PubMed:17585783). The biological function and the GSH- dependent property of PTGES2 is still under debate (PubMed:18198127, PubMed:17585783). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy- 5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:17585783) (By similarity). {ECO:0000250|UniProtKB:Q9N0A4, ECO:0000269|PubMed:12804604, ECO:0000269|PubMed:17585783, ECO:0000269|PubMed:18198127}. K9N7C7 EBI-26374966 0.35 P0C6X7 EBI-26377188 0.35 P0DTD1 EBI-25491011 0.53 Q01780 EBI-373752 0.00 P01106 EBI-1237540 0.35 P16104 EBI-2564373 0.35 Q5NFN4 EBI-2803788 0.00 P0DOE9 EBI-6138583 0.35 P42858 EBI-6452059 0.40 Q5VU69 EBI-10308949 0.56 Q8IWL3 EBI-13943458 0.35 Q13296 EBI-21513670 0.35 P61421 EBI-21518921 0.35 P80370 EBI-21555448 0.35 Q07954 EBI-21684279 0.35 O14949 EBI-21689809 0.35 O60518 EBI-21713634 0.35 Q9UG63 EBI-21764870 0.35 Q8N140 EBI-21773860 0.35 E9PK12 EBI-21841096 0.35 Q0VDI3 EBI-21891210 0.35 Q6UWI4 EBI-21898440 0.35 O75208 EBI-21930142 0.35 O00483 EBI-21930681 0.35 Q9C002 EBI-21935327 0.35 P07550 EBI-20801899 0.37 A0A0H3LG06 EBI-25401076 0.35 P0DOF2 EBI-25603126 0.35 GO:0035578 GO:0005829 GO:0005576 GO:0000139 GO:0016021 GO:0005739 GO:0005634 GO:0048471 GO:0036134 GO:0003677 GO:0043295 GO:0020037 GO:0016829 GO:0050220 GO:0019371 GO:0006629 GO:0045893 GO:0046903 Transmembrane UniProt Sequence Analysis {ECO:0000255} MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH 377