Q9Y217 Myotubularin-related MTMR6 9606 None SL-0198 Cytoplasm {ECO:0000269|PubMed:19038970}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:19038970}. Endoplasmic reticulum {ECO:0000269|PubMed:19038970}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q8VE11}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19038970}. Note=Localizes to ruffles during EGF-induced macropinocytosis (By similarity). Colocalizes with MTMR9 to the perinuclear region (PubMed:19038970). Partially localizes to the endoplasmic reticulum (PubMed:19038970). Co-localizes with RAB1B to the endoplasmic reticulum-Golgi intermediate compartment and to the peri- Golgi region (By similarity). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000250|UniProtKB:Q8VE11, ECO:0000269|PubMed:19038970}. UNIPROT Q9Y217 UNIPROT B2RBB5 UNIPROT B3KSB4 UNIPROT Q5JRG6 UNIPROT Q86TB7 UNIPROT Q86YH4 UNIPROT Q96P80 PDB 2YF0 Pfam PF06602 PROSITE PS51339 PROSITE PS00383 OMIM 603561 DisGeNET 9107 Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598). Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:16847315, ECO:0000269|PubMed:19038970, ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:24591580, ECO:0000305|PubMed:24591580}. P00533 EBI-32720286 0.27 Q6ZMQ8 EBI-20980286 0.37 Q96QG7 EBI-8657967 0.85 P41182 EBI-765648 0.35 P13631 EBI-3912831 0.37 P14373 EBI-10325112 0.56 Q13287 EBI-10325124 0.56 Q5JR59 EBI-10325134 0.56 Q9Y2J4 EBI-10325166 0.56 Q86X19 EBI-11372615 0.27 Q96LK0 EBI-11376319 0.27 Q15468 EBI-11383475 0.27 Q5SW79 EBI-11385552 0.27 P49286 EBI-11577362 0.00 Q9NXW9 EBI-14032135 0.37 Q8N5Z5 EBI-21592259 0.35 P32320 EBI-21622979 0.35 P14091 EBI-21699601 0.35 O95229 EBI-21701899 0.35 P48544 EBI-21754197 0.35 O00506 EBI-21762390 0.35 Q9Y216 EBI-21836819 0.35 Q93088 EBI-21899859 0.35 P49789 EBI-21901559 0.40 O43493 EBI-16800265 0.27 Q8IWU2 EBI-20979922 0.37 Q15303 EBI-20980456 0.37 P21860 EBI-20981026 0.37 Q01974 EBI-20981820 0.37 Q13308 EBI-20982464 0.37 Q92878 EBI-20927160 0.40 P0DOF2 EBI-25603126 0.35 P69479 EBI-25568051 0.35 P35226 EBI-27109494 0.35 P11362 EBI-32721578 0.27 P21802 EBI-32721907 0.27 P22455 EBI-32722168 0.27 GO:0005737 GO:0005829 GO:0005783 GO:0005793 GO:0005635 GO:0048471 GO:0032587 GO:0052629 GO:0106018 GO:0004438 GO:0004722 GO:0004725 GO:0006897 GO:0006661 GO:0046856 GO:0006470 Peripheral UniProt Curator Inference {ECO:0000305} MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLALTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESPNLKTSLCFKEQTLLPVNDALRTIEGSSPADNRYSEYAEEFSKSEPAVVSLEYGVARMTC 621