Q9Z0P5 Twinfilin-2 Twf2 10090 None SL-0198 Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19955359}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10406962}. Cell projection, stereocilium {ECO:0000269|PubMed:19774077, ECO:0000269|PubMed:19955359}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. Isoform 2 found also along myofibrils in cardiomyocytes (PubMed:18837697). Localized in cochlea hair cells to the tips of the middle and short rows of stereocilia (PubMed:19955359). {ECO:0000269|PubMed:18837697, ECO:0000269|PubMed:19955359}. UNIPROT Q9Z0P5 UNIPROT Q3TD06 UNIPROT Q3TZG2 UNIPROT Q8BN77 UNIPROT Q9DCK8 PDB 7DS3 Pfam PF00241 PROSITE PS51263 Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. {ECO:0000269|PubMed:18837697, ECO:0000269|PubMed:19955359}. P52927 EBI-9986179 0.35 Q93KQ6 EBI-16142792 0.35 GO:0005884 GO:0005737 GO:0005829 GO:0030175 GO:0030426 GO:0030027 GO:0030016 GO:0048471 GO:0032420 GO:0051015 GO:0003785 GO:0005524 GO:0005546 GO:0005080 GO:0030042 GO:0051016 GO:0030030 GO:0071363 GO:0071300 GO:0035556 GO:0030837 GO:0045773 GO:0010592 GO:0010976 GO:0032956 GO:0010591 GO:0032532 GO:0042989 Unknown UniProt Sequence Analysis MAHQTGIHATEELKEFFAKARAGSIRLIKVIIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSLAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTEPTNVAQLPSRIPRDAARYHFFLYKHTHEGDALESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFQLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGEDS 349