Q9Z270 Vesicle-associated Vapa 10116 None SL-0178 SL-0182 Endoplasmic reticulum membrane {ECO:0000269|PubMed:24262037}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9P0L0}. Cell membrane {ECO:0000250|UniProtKB:Q9P0L0}; Single-pass type IV membrane protein {ECO:0000305}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9P0L0}. Nucleus membrane {ECO:0000269|PubMed:24262037}. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells. {ECO:0000250|UniProtKB:Q9P0L0}. UNIPROT Q9Z270 UNIPROT Q6P723 PDB 1Z9L PDB 1Z9O Pfam PF00635 PROSITE PS50202 Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (By similarity). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (By similarity). With OSBPL3, may regulate ER morphology (By similarity). May play a role in vesicle trafficking (PubMed:19289470). {ECO:0000250|UniProtKB:Q9P0L0, ECO:0000269|PubMed:19289470}. P21708 EBI-7626952 0.35 P37840 EBI-2909386 0.35 Q8K4M9 EBI-15554458 0.65 Q9Z270 EBI-15554502 0.56 Q9BYV6 EBI-21998606 0.35 Q5XIE8 EBI-26438079 0.35 GO:0005923 GO:0005783 GO:0005789 GO:0000139 GO:0016021 GO:0016020 GO:0015630 GO:0031965 GO:0005886 GO:0031982 GO:0033149 GO:0042802 GO:0008017 GO:0019904 GO:0046982 GO:0044877 GO:0008219 GO:0035627 GO:0090114 GO:0006888 GO:0044828 GO:0031175 GO:0015914 GO:0044829 GO:0070972 GO:0006686 GO:0015918 GO:0019076 Transmembrane UniProt Sequence Analysis {ECO:0000255} MASASGAMAKHEQILVLDPPSDLKFKGPFTDVVTTNLKLQNPSDRKVCFKVKTTAPRRYCVRPNSGVIDPGSIVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNISDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPLPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSAVSFRDNVTSPLPSLLVVIAAIFIGFFLGKFIL 249