NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Brain protein I3 - Homo sapiens - NucEnvDB

Brain protein I3 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Brain protein I3
Accession Code	O95415
Gene	BRI3
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 125)
MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPAAPPPPPYPYLVTGIPTHHPRVYNIHSRTVTRYPANSIVVVGGCPVCRVGVLEDCFTFLGIFLAIILFPFGFICCFALRKRRCPNCGATFA

Subcellular Location

Description
Lysosome membrane {Curator InferencePubMed:14592447}; Multi-pass membrane protein {Sequence Analysis}. [Isoform 1]: Cytoplasm, perinuclear region {Experimental EvidencePubMed:30983867}. Note=Co-localizes with MGAT1 and IFITM3 at the perinuclear region. {Experimental EvidencePubMed:30983867}. [Isoform 2]: Cytoplasm {Experimental EvidencePubMed:30983867}. Nucleus {Experimental EvidencePubMed:30983867}. Note=Diffuse localization in the cytoplasm and nucleus. {Experimental EvidencePubMed:30983867}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Azurophil Granule Membrane (GO:0035577) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055). {Experimental EvidencePubMed:14592447, Experimental EvidencePubMed:20538055}.
Assigned Ontology terms

Biological Process
Molecular Function	Identical Protein Binding (GO:0042802)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q01628	Interferon-induced transmembrane protein 3	EBI-25503997	0.54
P26572	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	EBI-25504004	0.54
Interactions with other proteins (7 interactors)

Partner (UniProt)		IntAct	Confidence score
A0A380PDF6	Putative amino-acid ABC transporter (Permease)	EBI-2874795	0.00
Q13021	MAL-like protein (Protein BENE)	EBI-24525743	0.56
O95870	Phosphatidylserine lipase ABHD16A (EC 3.1.-.-) (Alpha/beta hydrolase domain-containing protein 16A) (Abhydrolase domain-containing protein 16A) (HLA-B-associated transcript 5) (hBAT5) (Monoacylglycerol lipase ABHD16A) (EC 3.1.1.23) (Protein G5)	EBI-24537575	0.56
P16871	Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)	EBI-25507926	0.37
Q8WY22	BRI3-binding protein (I3-binding protein) (Cervical cancer 1 proto-oncogene-binding protein KG19) (HCCRBP-1)	EBI-25504211	0.57
P46934	E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)	EBI-30832228	0.44
P46937	Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)	EBI-30846229	0.44

Cross-References

Database	Links
UNIPROT	O95415 D6W5R8 F5GXW6 Q8WV52 Q9UIC6
Pfam	PF10164
OMIM	615628
DisGeNET	25798

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