NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Vacuolar protein sorting-associated protein 53 homolog - Caenorhabditis elegans - NucEnvDB

Vacuolar protein sorting-associated protein 53 homolog (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Vacuolar protein sorting-associated protein 53 homolog
Accession Code	P34561
Gene	vps
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 798)
MEEPTTSELKLSDNVMNEISDMCITEYCKPNMSLMAQINELFPTEQSLTQLDSIIASVEGEIGELDNELAYLVETNANVSERGEEALKHAQDAMIELEKSIGSIRERTKSSDEIVREMTRDIKQLDIAKR NLTASITTLHHLHILLTGVESLGAWVDKKDYSSIARQLPAILNVLQLFDAYKESDQIANLSGQLDKLKASLTIQLAKDLKNAFQTGQLSDRITDMCRVAAALEGNVKENFVKWFIEQQLSEYVIIYADNE EGAWLDKVDDRYKWFVRKLTDFERAGLSNIFPADWHMGRRLTSEFCTVTRDILYRIMTRRRQDLDWKLLGHAIQHTKMFEALLTKRFPEKDGISFEKAIWSVFDTFLDVFINAQEKTLNEFLDTCASKIR SGEEKPSRESSTHAVPFPSSADMFLLLKKVITESSKLSSEPDALIRDVIGVVRVCLRGYATSCLVAFLPSLGSQQSGAANLFSLIREEIAYPRLTPDQQFLVCCILATADWCAETSIQLQEKLSQRIPGV DISQETEAFYSITNQSLQVLVQDVESTCDAALQSISKVNWTAVDCVGDESPFIGSMRAHLRQAVPLIRDMLSDRRKYFAHFCLKLATQLAHKFVGSLFRCRTISTHGAEQLLLDTHSLKTFLLSVPSIDS IINSKPPTAYVTSVNAALTKAEMILKVVMCSLETVDEFVEQYIKLLPASDAAEMQKVLEMKGVKRQEHSAVLNAYRLKIGASGSDPIQQSNSLTSRIGGALPTVGSAASVSEAFNAVVSMAADGLSDQAV TSSIDKLKRFERLVKRQL

Subcellular Location

Description
Golgi apparatus, trans-Golgi network membrane {By Similarity}; Peripheral membrane protein {By Similarity}. Endosome membrane {By Similarity}; Peripheral membrane protein {By Similarity}. Perikaryon {ECO:0000269\|PubMed:27191843}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:27191843}. Note=Co-localizes with rab-2 to perinuclear puncta in the perikaryon. {ECO:0000269\|PubMed:27191843}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250}
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Endosome Membrane (GO:0010008) GARP Complex (GO:0000938) Perikaryon (GO:0043204) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) (PubMed:21613545). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (PubMed:21613545). Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1 (PubMed:27191843). Important for neuronal function (PubMed:27191843). {Experimental EvidencePubMed:21613545, Experimental EvidencePubMed:27191843}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Dense Core Granule Transport (GO:1904810) Positive Regulation Of Dense Core Granule Transport (GO:1904811) Positive Regulation Of Locomotion Involved In Locomotory Behavior (GO:0090326) Regulation Of Brood Size (GO:0060378) Retrograde Transport, Endosome To Golgi (GO:0042147)
Molecular Function

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
G5EFV8	Vacuolar protein sorting-associated protein 52 homolog	EBI-6395189	0.54
Interactions with other proteins (6 interactors)

Partner (UniProt)		IntAct	Confidence score
O01839	Vacuolar protein sorting-associated protein 51 homolog (Protein fat-free homolog)	EBI-6394905	0.51
Q22639	Vacuolar protein sorting-associated protein 54	EBI-6395197	0.54
H2KZ72	Cuticlin-like protein 19	EBI-6421128	0.27
Q21499	Golgi SNAP receptor complex member 2	EBI-6421104	0.27
O18230	t-SNARE coiled-coil homology domain-containing protein	EBI-6421120	0.27
Q20797	Putative syntaxin-5	EBI-6421112	0.27

Cross-References

Database	Links
UNIPROT	P34561 E5QCF9
Pfam	PF04100

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