NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Centrosome-associated protein CEP250 - Mus musculus - NucEnvDB

Centrosome-associated protein CEP250 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Centrosome-associated protein CEP250
Accession Code	Q60952
Gene	Cep250
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 2414)
METGSPGLNMKPQSLQLVLEGQVLALQQQMAENQAASWRKLKNSQEAQKRQATLVRKLQAKVLQYRSWCQDLEKRLEATGGLIPQRWESVEEPNLEQLLIRLEEEQQRCESLVEVNTELRLHMEKADVVN KALQEDVEKLTVDWSRARDELVRKESQWRMEQEFFKGYLRGEHGRLLNLWREVVTFRRHFLKMKSATDRDLTELKAEHARLSGSLLTCCLRLTLRAQSRESSGSGRTEESEPARLLLLVAKTQALEKEAH EKSQELMQLKSHGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRETMEILETNHAELMEHEASLSRNAQEEKLSLQQVIKAITQALASVEEEDTVTQSSGHEDSLQSDCNGLSQFDPQDPDRALT LVQSVLTRRQQAVQDLRQQLSGCQEAMSFLQQQHDQWEEEGRALREKLQKLTGERDALAGQTVGLQGEVDSLSRERELLQKARGELQQQLEVLEQEAWRLRRMNMELQLQGDSAQGEKLEQQEELHLAVR ERERLQETLVGLEAKQSESLSELLTLREALESSRLEGELLKQERVEVAAALARAEQSIVELSGSENSLKAEVADLRAAAVKLGALNEALALDKVELNQQLLQLEQENQSLCSRVEAAEQLRSALQVDLAE AERRREALWEKKTQLETQLQKAEEAGAELQAELRGTREEKEELKDKLSEAHHQQETATAHLEQLHQDAERQEETLARAVQEKEALVRERAALEVRLQAVERDRQDLTEHVLGLRSAKEQLESNLFEAQQQ NSVIQVTKGQLEVQIQTIIQAKEVIQGEVKCLKLELDAERTRAEQEWDAVARQLAQAEQEGQASLERQKVAHEEEVNRLQEKWEKERSWLQQELDKTLETLERERAELETKLREQQTEMEAIRAQREEER SQADSALYQMQLETEKERVSLLETLLRTQKELADASQQLERLRQDMKIQKLKEQETTGMLQAQLQETQQELKEAAQQHRDDLAAFQKDKLDLQKQVEDLMSQLVAHDDSQRLVKEEIEEKVKVAQECSRI QKELEKENASLALSLVEKEKRLLILQEADSVRQQELSSLRQDIQEAQEGQRELGVQVELLRQEVKEKEADFVAREAQLLEELEASRVAEQQLRASLWAQEAKATQLQLQLRSTESQLEALVAEQQPENQA QAQLASLCSVLQQALGSACESRPELRGGGDSAPTLWGPDPDQNGASRLFKRWSLPTALSPEAVALALQKLHQDVWKARQARDDLRDQVQKLVQRLTDTEAQKSQVHSELQDLQRQLSQSQEEKSKWEGRQ NSLESELRDLHETAASLQSRLRQAELQKMEAQNDRELLQASKEKLSAQVEHLQACVAEAQAQADAAAVLEEDLRTARSALKLKNEELESERERAQALQEQGELKVAQGKALQENLALLAQTLSNREREVE TLQAEVQELEKQREMQKAALELLSLDLKKRSREVDLQQEQIQELEQCRSVLEHLPMAVQEREQKLSVQRDQIRELENDREAQRSVLEHQLLDLEQKAQVIESQRGQIQDLKKQLGTLECLALELEESHHK VESQQKMITELEGQREMQRVALTHLTLDLEERSQELQAQSSQLHELENHSTHLAKELQERDQEVTSQRQQIDELQKQQEQLAQALERKGQELVLQKERIQVLEDQRTLQTKILEEDLEQIKHSLRERSQE LASQWQLVHERADDGKSPSKGQRGSLEHLKLILRDKEKEVECQQERIQELQGHMGQLEQQLQGLHRKVGETSLLLTHREQETATLQQHLQEAKEQGELREQVLQGQLEEAQRDLAQRDHELETLRQEKQQ TQDQEESMKLKTSALQAALEQAHATLKERQGELEEHREQVRRLQEELEVEGRQVRALEEVLGDLRAESREHEKAVLALQQRCAEQAQEHEAEARTLQDSWLQAQATLTEQEQELAALRAENQYSRRQEEA AVSQAEALQEALSKAQAALQEKEQSLLEQAELSHTLEASTAALQATLDTCQASARQLEEALRIREGEIQAQALQHHEVTQHLQQELCQKKEELRQLLEKAGARRSQENGIQEKQSLEQERQEETRRLLES LKELQLTVAQREEEILMLREASSPRHRALPAEKPALQPLPAQQELERLQTALRQTEAREIEWREKAQDLALSLAQSKASISSLQEITMFLQASVLERESEQQRLQEELVLSRQALEEQQSGGPHSTSRAD QGPKVGQGSQSGEVETEPSPGVEEKERLTQRLERLQQAVAELEVDRSKLQCHNAQLRTALEQVERERRKLKRDSVRASRAGSLEARETMTSSPTQQDGRGSQRGSSDSVLVVELQREVALLRAQLALERK QRQDYIARSVQTSRELAGLHHSLSHSLLTVAQAPEATVLEAETRKLDESLNQSLTSPGPCLLHPSLDTTQNTHR

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:16339073}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {Experimental EvidencePubMed:16339073}. Cytoplasm, cytoskeleton, cilium basal body {Experimental EvidencePubMed:16339073, ECO:0000269\|PubMed:30998843}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269\|PubMed:28005958}. Photoreceptor inner segment {ECO:0000269\|PubMed:30998843}. Note=Component of the core centrosome where it is found at the proximal ends of centrioles.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Centriole (GO:0005814) Centrosome (GO:0005813) Ciliary Basal Body (GO:0036064) Perinuclear Region Of Cytoplasm (GO:0048471) Photoreceptor Inner Segment (GO:0001917) Photoreceptor Outer Segment (GO:0001750) Protein-Containing Complex (GO:0032991) Spindle Pole Centrosome (GO:0031616)

Biology & Function

Description
May be involved in ciliogenesis. Probably plays an important role in centrosome cohesion during interphase. {By SimilarityUniProtKB:Q9BV73}.
Assigned Ontology terms

Biological Process	Centriole-Centriole Cohesion (GO:0010457) Cilium Assembly (GO:0060271) Detection Of Light Stimulus Involved In Visual Perception (GO:0050908) Mitotic Cell Cycle (GO:0000278) Non-Motile Cilium Assembly (GO:1905515) Positive Regulation Of Protein Localization To Centrosome (GO:1904781) Protein Localization (GO:0008104) Protein Localization To Organelle (GO:0033365) Regulation Of Centriole-Centriole Cohesion (GO:0030997)
Molecular Function	Protein C-Terminus Binding (GO:0008022) Protein Domain Specific Binding (GO:0019904) Protein Kinase Binding (GO:0019901)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q8NFH4	Nucleoporin Nup37	EBI-11075169	0.35
Interactions with other proteins (7 interactors)

Partner (UniProt)		IntAct	Confidence score
Q8BH43	Actin-binding protein WASF2 (Protein WAVE-2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2)	EBI-651063	0.37
Q9P2X0	Dolichol-phosphate mannosyltransferase subunit 3 (Dolichol-phosphate mannose synthase subunit 3) (DPM synthase subunit 3) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 3) (Mannose-P-dolichol synthase subunit 3) (MPD synthase subunit 3) (Prostin-1)	EBI-11075169	0.35
Q5JTD0	Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4)	EBI-11075169	0.35
P53618	Coatomer subunit beta (Beta-coat protein) (Beta-COP)	EBI-11075169	0.35
P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	EBI-11075169	0.35
Q8IYS2	Uncharacterized protein KIAA2013	EBI-11075169	0.35
Q8BHC1	Ras-related protein Rab-39B	EBI-11568621	0.35

Cross-References

Database	Links
UNIPROT	Q60952 E9QMB2 Q2I8G3 Q3UTR4 Q6PFF6 Q8BLC6

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