NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Cytoskeleton-associated protein 4 - Mus musculus - NucEnvDB

Cytoskeleton-associated protein 4 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Cytoskeleton-associated protein 4
Accession Code	Q8BMK4
Gene	Ckap4
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 575)
MPSAKQRGSKGGHGAASPSDKGAHPSGGADDVAKKPPAAPQQPQPPAPHPPQHPQNQAHRGGHRGRSSAATANASSASCSRRLGRVLNFLFYLSLVAAAAFSGWYVHHVLEEVQQVRRGHQDFSRQRDEL GQGLQGVEQKVQSLQATFGTFESLLRNSQHKQDLTEKAVKEGESELNRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTDVQKRSQKEINEVKMKVASLEESKG DRSQDVKTLKDAVKEVQASMMSRERDIEALKSSLQTMESDVYTEVRELVSLKQEQQAFKQAADSERLALQALTEKLLRSEESSSRLPEDIRRLEEELQQLKVGAHGSEEGAVFKDSKALEELQRQIEGLG ARLQYVEDGVYSMQVASARHTESLESLLSKSQEYEQRLAMLQEHVGNLGSSSDLASTVRSLGETQLALSSDLKELKQSLGELPGTVESLQEQVLSLLSQDQAQAEGLPPQDFLDRLSSLDNLKSSVSQVE SDLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFLKVEKIHEKI

Subcellular Location

Description
Endoplasmic reticulum membrane {Experimental EvidencePubMed:32075961}; Single-pass type II membrane protein {Curator Inference}. Cell membrane {By SimilarityUniProtKB:Q07065}; Single- pass type II membrane protein {Curator Inference}. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF-stimulation. {ECO:0000250}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cell Surface (GO:0009986) Cytoskeleton (GO:0005856) Endoplasmic Reticulum (GO:0005783) Endoplasmic Reticulum Membrane (GO:0005789) Lipid Droplet (GO:0005811) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Rough Endoplasmic Reticulum (GO:0005791)

Biology & Function

Description
High-affinity epithelial cell surface receptor for APF. {By Similarity}. Mediates the anchoring of the endoplasmic reticulum to microtubules. {By Similarity}.
Assigned Ontology terms

Biological Process
Molecular Function

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q8BRE0	Protein RD3	EBI-20718973	0.35
Interactions with other proteins (3 interactors)

Partner (UniProt)		IntAct	Confidence score
P68510	14-3-3 protein eta	EBI-8586548	0.35
P14094	Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)	EBI-20566937	0.35
P07602	Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]	EBI-21347829	0.35

Cross-References

Database	Links
UNIPROT	Q8BMK4 B2RRB4 Q8BTK8 Q8R3F2

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK