NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Adenylate cyclase type 10 - Homo sapiens - NucEnvDB

Adenylate cyclase type 10 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Disease Associations Interactions Cross-References

General Information

Protein Information
Protein Name	Adenylate cyclase type 10
Accession Code	Q96PN6
Gene	ADCY10
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 1610)
MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEILNYHIS AIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSLEIHGLFETQEWEEGLDIRVKIGLAAGHISMLVFGDE THSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYY PSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMH ITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTV RHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKVMFGMACLICNR KEDYPLLGRNKEINYFMYTMKKFLISNSSQVLMYEGLPGYGKSQILMKIEYLAQGKNHRIIAISLNKISFHQTFYTIQMF MANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIFHVQFPISREISRMSTLKKQKQLEILFMKILKLIVKEERII FIIDEAQFVDSTSWRFMEKLIRTLPIFIIMSLCPFVNIPCAAARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVSCISK ELDSYLGEGSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWNNLFKYSIKLTEKLNMVTLHSDKESEEVCHLTSGV RLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKMMIKTLATLVESNIFYCFRNGKELQ KALKQNDPSFEVHYRSLSLKPSEGMDHGEEEQLRELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEED AHRCDHCRGRDFIPYHHFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAFFPENRSPEEIREKILNFFDH VLTKMKTSDEDIIPLESCQCEEILEIVILPLAHHFLALGENDKALYYFLEIASAYLIFCDNYMAYMYLNEGQKLLKTLKK DKSWSQTFESATFYSLKGEVCFNMGQIVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKK RLAQLYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSLYHHLAGYKGVWFKYEVMAME HIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGSRALQMWALLQNPNRHYQSLCRLSRCLLLNSRYPQLIQVLG RLWELSVTQEHIFSKAFFYFVCLDILLYSGFVYRTFEECLEFIHQYENNRILKFHSGLLLGLYSSVAIWYARLQEWDNFY KFSNRAKNLLPRRTMTLTYYDGISRYMEGQVLHLQKQIKEQSENAQASGEELLKNLENLVAQNTTGPVFCPRLYHLMAYV CILMGDGQKCGLFLNTALRLSETQGNILEKCWLNMNKESWYSTSELKEDQWLQTILSLPSWEKIVAGRVNIQDLQKNKFL MRANTVDNHF

Structure Viewer (PDB: 4CLW)

Subcellular Location

Description
Cell membrane {Experimental EvidencePubMed:15659711}; Peripheral membrane protein {Experimental EvidencePubMed:15659711}; Cytoplasmic side {Experimental EvidencePubMed:15659711}. Cytoplasm, cytoskeleton {ECO:0000269\|PubMed:12475901, Experimental EvidencePubMed:15659711}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:12475901, Experimental EvidencePubMed:15659711}. Nucleus {ECO:0000269\|PubMed:12475901, Experimental EvidencePubMed:15659711}. Cell projection, cilium {ECO:0000269\|PubMed:17591988}. Cytoplasm {ECO:0000269\|PubMed:12475901}. Mitochondrion {ECO:0000269\|PubMed:12475901}. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. {ECO:0000269\|PubMed:12475901, Experimental EvidencePubMed:15659711}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	Experimental Evidence {ECO:0000269\|PubMed:15659711}
Assigned Ontology terms

Cellular Component	Apical Plasma Membrane (GO:0016324) Basal Part Of Cell (GO:0045178) Cilium (GO:0005929) Cytoplasm (GO:0005737) Cytoskeleton (GO:0005856) Cytosol (GO:0005829) Dendrite (GO:0030425) Extracellular Region (GO:0005576) Growth Cone (GO:0030426) Mitochondrion (GO:0005739) Neuronal Cell Body (GO:0043025) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988). {By SimilarityUniProtKB:Q8C0T9, Experimental EvidencePubMed:15659711, Experimental EvidencePubMed:17591988, Experimental EvidencePubMed:24567411, Experimental EvidencePubMed:24616449, Experimental EvidencePubMed:25040695}.
Assigned Ontology terms

Biological Process	CAMP Biosynthetic Process (GO:0006171) Cellular Response To Inorganic Substance (GO:0071241) Epithelial Cilium Movement Involved In Extracellular Fluid Movement (GO:0003351) Intracellular Signal Transduction (GO:0035556) Positive Regulation Of Apoptotic Process (GO:0043065) Spermatogenesis (GO:0007283)
Molecular Function	Adenylate Cyclase Activity (GO:0004016) ATP Binding (GO:0005524) ATPase Binding (GO:0051117) Bicarbonate Binding (GO:0071890) Magnesium Ion Binding (GO:0000287) Manganese Ion Binding (GO:0030145)

Disease associations

Description
Hypercalciuria absorptive 2 (HCA2) [MIM:143870]: A common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. {Experimental EvidencePubMed:11932268}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
Database Associations
OMIM	143870 605205
DisGeNET	55811

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P12270	Nucleoprotein TPR	EBI-20930080	0.40

Cross-References

Database	Links
UNIPROT	Q96PN6 B4DZF0 F5GWS5 O95558 Q5R329 Q5R330 Q8WXV4 Q9NNX0
PDB	4CLF 4CLK 4CLL 4CLP 4CLS 4CLT 4CLU 4CLW 4CLY 4CLZ 4CM0 4CM2 4OYA 4OYB 4OYI 4OYM 4OYO 4OYP 4OYW 4OYX 4OYZ 4OZ2 4OZ3 4UST 4USU 4USV 4USW 5D0R 5IV3 5IV4 7OVD
Pfam	PF00211
PROSITE	PS50125
OMIM	143870 605205
DisGeNET	55811

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