NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Myotubularin-related protein 2 - Mus musculus - NucEnvDB

Myotubularin-related protein 2 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Myotubularin-related protein 2
Accession Code	Q9Z2D1
Gene	Mtmr2
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 643)
MEKSSSCESLGAQLPAARLPSEDSLSSASTSHSENSVHTKSASAISSDSISTSADNFSPDLRVLREANKLAEMEEPALLPGENIKDMAKDVTYICPFTGAVRGTLTVTSYRLYFKSMERDPPFVLDASLG VISRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNGLPLFAFEYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVAS FRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPTIEETHWLSNLESTHWLE HIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTF LCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPIHSRYKELLAKRAELQRKVEELQREISNRSTSSSERASSPAQCVTPVQTVV

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:14530412, Experimental EvidencePubMed:16399794, Experimental EvidencePubMed:23297362}. Early endosome membrane {By SimilarityUniProtKB:Q13614}; Peripheral membrane protein {By SimilarityUniProtKB:Q13614}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:14530412}. Cell projection, axon {Experimental EvidencePubMed:23297362}. Endosome membrane {Experimental EvidencePubMed:23297362}; Peripheral membrane protein {ECO:0000305}. Note=Partly associated with membranes (PubMed:14530412, PubMed:23297362). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). {Experimental EvidencePubMed:14530412, Experimental EvidencePubMed:16399794, Experimental EvidencePubMed:23297362}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	Curator Inference {ECO:0000305}
Assigned Ontology terms

Cellular Component	Axon (GO:0030424) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Dendrite (GO:0030425) Dendritic Spine (GO:0043197) Early Endosome Membrane (GO:0031901) Intracellular Membrane-Bounded Organelle (GO:0043231) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Postsynaptic Density (GO:0014069) Synaptic Membrane (GO:0097060) Synaptic Vesicle (GO:0008021) Vacuolar Membrane (GO:0005774)

Biology & Function

Description
Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:12045210, PubMed:16399794). Has phosphatase activity towards pho sphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate (PubMed:12045210, PubMed:16399794). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5- trisphosphate (PubMed:12045210, PubMed:16399794). Stabilizes SBF2/MTMR13 at the membranes (PubMed:23297362). Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (PubMed:23297362). {Experimental EvidencePubMed:12045210, Experimental EvidencePubMed:16399794, Experimental EvidencePubMed:23297362}.
Assigned Ontology terms

Biological Process	Dendritic Spine Maintenance (GO:0097062) Dephosphorylation (GO:0016311) Inositol Phosphate Dephosphorylation (GO:0046855) Myelin Assembly (GO:0032288) Myelination (GO:0042552) Negative Regulation Of Endocytosis (GO:0045806) Negative Regulation Of Excitatory Postsynaptic Potential (GO:0090394) Negative Regulation Of Myelination (GO:0031642) Negative Regulation Of Receptor Catabolic Process (GO:2000645) Negative Regulation Of Receptor Internalization (GO:0002091) Neuron Development (GO:0048666) Phosphatidylinositol Dephosphorylation (GO:0046856) Phosphatidylinositol Metabolic Process (GO:0046488) Positive Regulation Of Early Endosome To Late Endosome Transport (GO:2000643) Regulation Of Phosphatidylinositol Dephosphorylation (GO:0060304)
Molecular Function	Identical Protein Binding (GO:0042802) Phosphatidylinositol Phosphate Phosphatase Activity (GO:0052866) Phosphatidylinositol-3,5-Bisphosphate 3-Phosphatase Activity (GO:0052629) Phosphatidylinositol-3-Phosphate Phosphatase Activity (GO:0004438)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O95248	Myotubularin-related protein 5	EBI-11064455	0.35
Q86WG5	Myotubularin-related protein 13	EBI-11064455	0.35
Interactions with other proteins (3 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9C0I1	Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein)	EBI-11064455	0.35
Q9UHQ1	Nuclear prelamin A recognition factor (Iron-only hydrogenase-like protein 2) (IOP2)	EBI-11064455	0.35
Q9NXD2	Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10)	EBI-11064455	0.35

Cross-References

Database	Links
UNIPROT	Q9Z2D1 B8JJF4 Q8VHA7
Pfam	PF02893 PF06602
PROSITE	PS51339 PS00383 PS50056

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