NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Muscular LMNA-interacting protein - Rattus norvegicus - NucEnvDB

Muscular LMNA-interacting protein (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Muscular LMNA-interacting protein
Accession Code	A0A096MK47
Gene	Mlip
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 807)
MEFEKHEQGNALKKNEKLEERVTFEYSDHMTFSCESKEERDQRILDYPSEVSGKNSQRKEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGATGNIATRPKSLAISSSLASDVVRPKVR GVDVKVSSHPEIPHGIAPQQKHGQLTSPTTSEQLAHKPPAFSFVSPTNQKTPPVPAKVSGTTVLEEFHIRRLDVHGASEEETATYFHTTAHDSPLPAWKGASTLVFSPSAQLPGSSLCGSNVADHTRGLA PEAQKKVSTSSALNPREDVRTSPSPASGASLRSPSASYIPVRIVMHSLSPSPKPLTSSSHGSLSTVCSQTSSSGNLSKSGLKSPVPSRLSLLTAILKSNPSHQRPLSPASCPTFSLNSLASSTLTLDQKI KQTPSTPKKSLSSCSLTTGSTEQEQASAESHQPCHLSFFSKTTPLSQAQPPSPPALASSSYAATDTEKIPGSTLRSSTTPPQSQTDLFSLADVPSVTPGLSPLSSSKGRKDGDLRAPEKNRNICTRPSTL SFIPPINESTALSSSGKCFHPSPALSDLIDRSKRTCSQRHSDQRPNPSALPTPPVSRAGSASHPHLGYSILPPESSLTQALQRSPSALHPSCGSATCPSRTGMPDSTASNRSSRVSTPSLPVSLTRTKEL ISPCALSMSAGPENKKPKQYKTKSSYKAFAAIPTNTLLLEQKALDEPARTESNSKASVSDLPVEHSSDSPSRPSQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTTSESQLTKPGVIRPVPIKSKLF LKKEEEVYEPNPFSKYLEDSSGLFSEQ

Subcellular Location

Description
Nucleus {By SimilarityUniProtKB:Q5FW52}. Nucleus envelope {By SimilarityUniProtKB:Q5FW52}. Nucleus, PML body {By SimilarityUniProtKB:Q5FW52}. Cell membrane, sarcolemma {By SimilarityUniProtKB:Q5FW52}; Peripheral membrane protein {By SimilarityUniProtKB:Q5FW52}; Cytoplasmic side {By SimilarityUniProtKB:Q5FW52}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:Q5FW52}
Assigned Ontology terms

Cellular Component	Nuclear Envelope (GO:0005635) Nuclear Lumen (GO:0031981) Nucleus (GO:0005634) PML Body (GO:0016605) Sarcolemma (GO:0042383)

Biology & Function

Description
Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy (PubMed:22343712, PubMed:26436652). Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD (By similarity). {By SimilarityUniProtKB:Q5FW52, Experimental EvidencePubMed:22343712, Experimental EvidencePubMed:26436652}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Cardiac Muscle Hypertrophy (GO:0010614) Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress (GO:1903243) Negative Regulation Of DNA-Templated Transcription (GO:0045892) Negative Regulation Of Transcription By RNA Polymerase II (GO:0000122) Positive Regulation Of Transcription By RNA Polymerase II (GO:0045944) Transcription By RNA Polymerase II (GO:0006366)
Molecular Function	Lamin Binding (GO:0005521) Transcription Corepressor Activity (GO:0003714)

Cross-References

Database	Links
UNIPROT	A0A096MK47 D4A3C4 Q569A0
Pfam	PF15274

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK