National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | E3 SUMO-protein ligase RanBP2 |
| Accession Code | A0A0B4K7J2 |
| Gene | Nup358 |
| Organism | Drosophila melanogaster (Taxonomy: 7227) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 2718) |
Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. |
| Nuclear Pore Complex | SL-0185 | The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active bidirectional transport of macromolecules such as proteins, RNAs etc across the double-membrane nuclear envelope.The NPC is composed of at least 30 distinct subunits known as Nucleoporins (NUPs). | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope (PubMed:17682050). Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway (PubMed:27979731, PubMed:17682050, PubMed:17682050). Plays a role in nuclear mRNA export by recruiting the mRNA transport complex composed of Nxt1 and sbr/Nxf1 to the NPC (PubMed:14729961). Essential during germline development for transposon silencing and piRNA biogenesis probably by regulating piwi localization to the nucleus (PubMed:29735528). During oogenesis, required to form granules that modulate the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769). {By SimilarityUniProtKB:P49792, Experimental EvidencePubMed:14729961, Experimental EvidencePubMed:17682050, Experimental EvidencePubMed:20547758, Experimental EvidencePubMed:27979731, Experimental EvidencePubMed:29735528, Experimental EvidencePubMed:31626769}. | Assigned Ontology terms |
Interactions with other proteins (7 interactors) |
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|---|---|---|---|
Database | Links |
| UNIPROT | A0A0B4K7J2 D3DMF2 Q8SWV7 Q9VBU7 |
| Pfam | PF00638 PF00641 |
| PROSITE | PS50196 PS50293 PS01358 PS50199 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory