NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Klaroid protein - Drosophila melanogaster - NucEnvDB

Klaroid protein (Drosophila melanogaster)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Klaroid protein
Accession Code	A0A0B4KEE4
Gene	koi
Organism	Drosophila melanogaster (Taxonomy: 7227)
Part of Reference Proteome?	Yes
Sequence (Length: 965)
MSENTYQIETRRRSRSKTPFLRSSCDHENCEHAGEEGHVHHLKRKSAAPNVQTIIEEHIVESSISKKTRAKAFAQLTSDYSSDDMTPDAKRKQNSITATVTSILTKRSGGATSTPRNRSQLETTQNTLNS AQEKLNQSNGNLSSGNVSDYLAYIEYRDAGEYWNKTPKTDYTYSELSPHRRQLAPGIVAMPNMSRKSLENHNDRVNYMVQQNPAQEEFIRRRYQSKYTQQVNYDSADELDATFGQQKQSWWLIRLIQLVV SSITTVWSRVTNLSATETTAYQNYHAKRQQSQQVGLWWKIVQTIGGGLASLLRYLYVFIGSVLSLDTWLLRSSDAENKSKKRFLIFLLILLPLLLLSGWLLLQEDQRSAYVQRAEALLPLPLSIFGSLRS RFSNAGATLKSWMEVPTVRSPQREAEAIKVNMASIEQNIQKALTAEEYENILNHVNSYVQQLVELKMQQHSKELAPQQIELFVKLMKENLKQIMYKTELSEKDLSDLAIKLKLELQSSGGWQDGAKLSQA NLEEITKLIKAEVHLHESHYTIQLDRIDFASLLERILAAPALADFVDARISLRVGELEPKESSGSSDAEVQIERLNREIAFIKLALSDKQAENADLHQSISNLKLGQEDLLERIQQHELSQDRRFHGLLA EIENKLSALNDSQFALLNKQIKLSLVEILGFKQSTAGGSAGQLDDFDLQTWVRSMFVAKDYLEQQLLELNKRTNNNIRDEIERSSILLMSDISQRLKREILLVVEAKHNESTKALKGHIREEEVRQIVKT VLAIYDADKTGLVDFALESAGGQILSTRCTESYQTKSAQISVFGIPLWYPTNTPRVAISPNVQPGECWAFQGFPGFLVLKLNSLVYVTGFTLEHIPKSLSPTGRIESAPRNFTVWGLEQEKDQEPVLFGD YQFEDNGASLQYFAVQNLDIKRPYEIVELRIETNHGHPTYTCLYRFRVHGKPPAT

Subcellular Location

Description
Membrane {Sequence Analysis}; Multi-pass membrane protein {Sequence Analysis}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:18820457}. Note=Lam is required for perinuclear localization of Koi. {ECO:0000269\|PubMed:18820457}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Obsolete Integral Component Of Nuclear Inner Membrane (GO:0005639) Meiotic Nuclear Membrane Microtubule Tethering Complex (GO:0034993) Nuclear Envelope (GO:0005635) Nuclear Periphery (GO:0034399) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (By similarity). Is required to nuclear migration in eye and to anchor klar in the nuclear membrane (PubMed:18820457). {By SimilarityUniProtKB:O94901, Experimental EvidencePubMed:18820457}.
Assigned Ontology terms

Biological Process	Double-Strand Break Repair Via Homologous Recombination (GO:0000724) Nuclear Envelope Organization (GO:0006998) Nuclear Migration (GO:0007097) Nucleus Localization (GO:0051647)
Molecular Function	Protein-Membrane Adaptor Activity (GO:0043495)

Cross-References

Database	Links
UNIPROT	A0A0B4KEE4
Pfam	PF07738
PROSITE	PS51469

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