NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

NADPH-dependent diflavin oxidoreductase 1 - Mus musculus - NucEnvDB

NADPH-dependent diflavin oxidoreductase 1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	NADPH-dependent diflavin oxidoreductase 1
Accession Code	A2AI05
Gene	Ndor1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 598)
MQVPQLLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVANLIREPLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSSSLCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPPCLG DDQHELGPDAAIDPWVGDLWEKIMVMYPVPLDIPEIPHGVPLPSKFIFQFLQEVPSIGAEELNIASSAPQTPPSELQPFLAPVITNQRVTGPQHFQDVRLIEFDITDSNISFAAGDVVFILPSNSEAHTQ QFCQVLCLDPNQFFTLKPREPGVPDPPGLPQPCTVWNLVSQYLDIASVPRRSFFELLACLSQHALEREKLLELSSARGQEELWEYCSRPRRTILEVLCDFPHTAGAIPPDYLLDLIPRIRPRAFSIASSL LAHPRRLQILVAVVKYQTRLKEPRHGLCSSWLASLNPGQAGPVRVPLWVRPGSLVFPKTPDTPIIMVGAGTGVAPFRAAIQERVAHGQTGNFLFFGCRQRDQDFYWQTEWQKLEQKGWLTLVTAFSREQE QKVYVQHRLRELGPLVWELLDGQGAYFYLAGNAKYLPTDVSEALMSIFQEEGRLSTADASAYLARLQQTLRFQTETWA

Subcellular Location

Description
Cytoplasm, perinuclear region {Sequence AnalysisHAMAP- Rule:MF_03178}. Note=Concentrated in perinuclear structure. {Sequence AnalysisHAMAP-Rule:MF_03178}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Intermediate Filament Cytoskeleton (GO:0045111) Nucleoplasm (GO:0005654) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (By similarity). In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (By similarity). {By SimilarityUniProtKB:Q9UHB4, Sequence AnalysisHAMAP- Rule:MF_03178}.
Assigned Ontology terms

Biological Process	Cell Death (GO:0008219) Cellular Response To Menadione (GO:0036245) Electron Transport Chain (GO:0022900) Iron-Sulfur Cluster Assembly (GO:0016226)
Molecular Function	Electron Transfer Activity (GO:0009055) FAD Binding (GO:0071949) Flavin Adenine Dinucleotide Binding (GO:0050660) FMN Binding (GO:0010181) NADP Binding (GO:0050661) NADPH Binding (GO:0070402) NADPH-Hemoprotein Reductase Activity (GO:0003958) Oxidoreductase Activity (GO:0016491) Oxidoreductase Activity, Acting On Iron-Sulfur Proteins As Donors, NAD Or NADP As Acceptor (GO:0016731) Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor (GO:0016653)

Cross-References

Database	Links
UNIPROT	A2AI05 Q3TQZ6 Q80WC5
Pfam	PF00667 PF00258 PF00175
PROSITE	PS51384 PS50902

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