NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Exocyst complex component 8 - Bos taurus - NucEnvDB

Exocyst complex component 8 (Bos taurus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Exocyst complex component 8
Accession Code	A4IF89
Gene	EXOC8
Organism	Bos taurus \| Cattle (Taxonomy: 9913)
Part of Reference Proteome?	Yes
Sequence (Length: 725)
MAMAMSDSGASRLRRQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRIQALAEETAQNLKRNVYQNYRQFIETAREISYLESEMYQLSHLLTEQKSSLESIPLTLLPAAAAAGAAAASGGEEGGGGAGGR DQLRGQTGFFPSPGGASRDGSGPGEEGKQRTLTTLLEKVEGCRHLLETPGQYLVYNGDLVEYEADHMAQLQRVHGFLMNDCLLVATWLPQRRGMYRYNALYPLDGLAVVNVKDNPPMKDMFKLLMFPESR IFQAENAKIKREWLEVLEETKRALSEKRRREQEEAAAPRGPPQVTPKASNPFEDEDDDEPTVPEIEEEKVDLSMEWIQELPEDLDVCIAQRDFEGAVDLLDKLNHYLEDKPSPPPVKELRARVDERVRQL TEVLVFELSPDRSLRGGPKATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKLCHVFFTSLLETAREFETDFAGTDSGCYSAFVVWARSAMGMFVDAFSKQVFDSKESLSTAAE CVRVAKEHCQQLGDIGLDLTFIVHALLVKDIQGALHSYKEIIIEATKHRNSEEMWRRMNLMTPEALGKLKEEMKSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHMVLLESLVEI ILVAVQHVDYSLRCEQDPEKKAFIRQNASFLYETVLPVVEKRFEEGVGKPAKQLQDLRNASRLIRVNPESTTSVV

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:O54924}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:O54924}. Cell projection, growth cone {By SimilarityUniProtKB:O54924}. Cell projection {By SimilarityUniProtKB:O54924}. Note=Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during NGF-induced neuronal differentiation (By similarity). Localizes at the leading edge of migrating cells (By similarity). {ECO:0000250, By SimilarityUniProtKB:O54924}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Exocyst (GO:0000145) Growth Cone (GO:0030426) Late Endosome (GO:0005770) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {By Similarity}.
Assigned Ontology terms

Biological Process	Endosome Organization (GO:0007032) Exocytosis (GO:0006887) Extracellular Matrix Disassembly (GO:0022617) Golgi To Plasma Membrane Transport (GO:0006893) Protein Localization (GO:0008104) Protein Transport (GO:0015031)
Molecular Function	Phosphatidylinositol Binding (GO:0035091) Small GTPase Binding (GO:0031267)

Cross-References

Database	Links
UNIPROT	A4IF89
Pfam	PF16528
PROSITE	PS50003

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