NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Amyloid-beta A4 precursor protein-binding family A member 1 - Mus musculus - NucEnvDB

Amyloid-beta A4 precursor protein-binding family A member 1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Amyloid-beta A4 precursor protein-binding family A member 1
Accession Code	B2RUJ5
Gene	Apba1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 842)
MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVVEGQQPSPSPPPPAGHEPEDHRGHPAPPPPPPPQEEEEEERGECLA RSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHVEAAQRRALPNHLHFHSLE HEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLH HYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGL PAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQR PVDGDSPSPGSSSPLGAESSSIPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDK TPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIV VLMARRRMPRSNSQENVEASHPSQDGKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLL NTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLV GLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQS VVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI

Structure Viewer (PDB: 6LNM)

Subcellular Location

Description
Cytoplasm {By Similarity}. Cytoplasm, perinuclear region {By Similarity}. Nucleus {By Similarity}. [Isoform 3]: Golgi apparatus.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Dendritic Spine (GO:0043197) Glutamatergic Synapse (GO:0098978) Golgi Apparatus (GO:0005794) Membrane (GO:0016020) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Presynaptic Active Zone Membrane (GO:0048787) Protein-Containing Complex (GO:0032991) Schaffer Collateral - CA1 Synapse (GO:0098685) Synaptic Vesicle (GO:0008021)

Biology & Function

Description
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity). Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D- aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). {By Similarity, Experimental EvidencePubMed:10846156}.
Assigned Ontology terms

Biological Process	Chemical Synaptic Transmission (GO:0007268) Establishment Of Localization In Cell (GO:0051649) Gamma-Aminobutyric Acid Secretion (GO:0014051) Glutamate Secretion (GO:0014047) In Utero Embryonic Development (GO:0001701) Intracellular Protein Transport (GO:0006886) Locomotory Behavior (GO:0007626) Multicellular Organism Growth (GO:0035264) Protein-Containing Complex Assembly (GO:0065003) Regulation Of Gene Expression (GO:0010468) Regulation Of Synaptic Vesicle Exocytosis (GO:2000300)
Molecular Function	Amyloid-Beta Binding (GO:0001540) PDZ Domain Binding (GO:0030165) Phosphatidylinositol-4,5-Bisphosphate Binding (GO:0005546) Protein-Containing Complex Binding (GO:0044877)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P61294	Ras-related protein Rab-6B (EC 3.6.5.2)	EBI-8840212	0.27
P20340	Ras-related protein Rab-6A (Rab-6)	EBI-8840609	0.44

Cross-References

Database	Links
UNIPROT	B2RUJ5 Q3UH49 Q8BMF2
PDB	6LNM
Pfam	PF00595 PF00640
PROSITE	PS50106 PS01179

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