NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein NEDD1 - Arabidopsis thaliana - NucEnvDB

Protein NEDD1 (Arabidopsis thaliana)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Protein NEDD1
Accession Code	B3H5K9
Gene	NEDD1
Organism	Arabidopsis thaliana \| Thale cress (Taxonomy: 3702)
Part of Reference Proteome?	Yes
Sequence (Length: 782)
MMSNLVEPSWRLLAASGGDTVKLFDVSADSGDPCVLSYTPSPGCAVNSVKWNHTNLVVASTGEDKKISLWRKNGQSLGTVPVTGKDGGDSAEECLSAISFSKKGSRYICSGGTGQIVKIWDLQRKLCIKK LKGHTSTITGVMYNCKDEHLASVSVGGDLIVHNLASGARATELKDPNGQVLRLLDYSRSSRHLLVTAGDDGTVHLWDTTGRSPKMSWLKQHSAPTAGVCFSPSNEKIIASVGMDKKLYTYDSGSRRSSSC IAYEAPFSSLAFGDNGYILVAGTSNGRVVFYDIRGKPQPVTVLHAFSNSEDVTSLSWQTSKPVIVNEKNYTSEMALLGSTVEDSVVIPDPLPSTTPSASQSAMAPGSRGVSASTVNASSVEQTPNRNHLW PSGPLGRLHALRANDSYNDDMGVFSPIIDVSSVEKWADSEGYNNKDHLVVDNKPSSLLFPSSSKGYSFGDNGSKEHPIFDWKPSSTSKQDDPRAAFSSFGSITPTASSKSEDSALTPPEAWGGDKFSEKF NQLANEKFSDKFSHLHAPSRLAVSSTGASTSGSMFSSSRDFPLSHGQTNFANASLEFPRIRDFSSTFETSSTQTDNNLPSSPLFTKGITAPGNIDSLRLSPNFTRRFSTYAERISTTSSFSDGASLSLGG SPKIKKTGSETREEVLNHLLARPETVVATEAGAMPLMNQGGLKQSQTDQQQVMGSSNFTLQLFQRTLEGTLDSFQNSIHDDVRNLHIEILRQFHMHEMEMSKVLSSILENQAEQMKELKLLRKENQELRQ RL

Subcellular Location

Description
Nucleus envelope {Experimental EvidencePubMed:19383896, Experimental EvidencePubMed:25438942}. Chromosome, centromere, kinetochore {Experimental EvidencePubMed:19383896}. Cytoplasm, cytoskeleton, phragmoplast {Experimental EvidencePubMed:19383896}. Cytoplasm, cytoskeleton, microtubule organizing center {Experimental EvidencePubMed:25438942}. Note=First detected in prophase on the nuclear envelope, where it appeared to cap the future spindle poles. Later detected along kinetochore microtubules (MTs) of the metaphase spindle, with more prominent signals toward the poles. In anaphase, detected with the shortening kinetochore fibers. In the developing phragmoplast, localized mainly toward the minus end of MTs. {Experimental EvidencePubMed:19383896}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Kinetochore (GO:0000776) Kinetochore Microtubule (GO:0005828) Nuclear Envelope (GO:0005635) Phragmoplast (GO:0009524)

Biology & Function

Description
Regulates microtubules organization in a centrosome- independent manner. Required for the spindle to be positioned correctly and for the function of gamma-tubulin in organizing phragmoplast microtubules (PubMed:19383896). Component of active gamma-tubulin ring complexes (gamma-TuRCs) associated with cortical microtubules in interphase cells (PubMed:25438942). Mediates gamma-TuRC recruitment to the nucleation sites and is important for determining the ratio of branched to parallel nucleation (PubMed:25438942). May mediate the localization of GCP2 and GCP3 to the nuclear envelope (PubMed:19383896). {Experimental EvidencePubMed:19383896, Experimental EvidencePubMed:25438942}.
Assigned Ontology terms

Biological Process	Cell Plate Assembly (GO:0000919) Embryo Sac Development (GO:0009553) Pollen Development (GO:0009555) Positive Regulation Of Cytokinesis (GO:0032467) Regulation Of Microtubule Nucleation (GO:0010968) Regulation Of Mitotic Spindle Organization (GO:0060236) Regulation Of Phragmoplast Microtubule Organization (GO:2000694)
Molecular Function	Gamma-Tubulin Complex Binding (GO:0140496)

Cross-References

Database	Links
UNIPROT	B3H5K9 B6EUA6 Q9FI89
Pfam	PF00400
PROSITE	PS00678 PS50082 PS50294

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