NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein asunder - Drosophila simulans - NucEnvDB

Protein asunder (Drosophila simulans)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Protein asunder
Accession Code	B4QX59
Gene	asun
Organism	Drosophila simulans (Taxonomy: 7240)
Part of Reference Proteome?	Yes
Sequence (Length: 689)
MFERNQKTIFVLDHTRYFSIASEEYISMDFLKGKPSGDGGATGAAGNATGSGGSQFSKSLWTCACESSIEYCRVVWDLFPGKKHVRFIVSDTAAHIVNTWSPSTQNMSHVMNAMVMVGVPSRNVPTSSDY SVIHGLRAAIEALAEPTDEQLAAMADLGTDELPRIPNKGRVICITSARDNTSMKSLEDIFNTVLVQQNTLAAPPAKKGLVIDHCHLVILNIVPLGVESLVTNRSLLKISPLLDVEIHTVSAPDISYKLTH LILNHYDLASTTVTNIPMKEEQNANSSANYDVEILHSRRAHSITCGPDFSLPTSIKQGATYETVTLKWCTPRGCGSAHLQPCLGQFLVTPVDVTSRPSSCLINFLLNGRSVLLEMPRKTGSKATSHMLSA RGGEIFVHSLCITRSCMDEAPSITDGPGGRVSDYRTAELGQLIKMSRMVPLKVKDPSAPPLTRRLPRYFPLTTSSSILFHLQRHISWLPHFLHLLVKEDMDKQDEVRCQQHIHELYKSASRGDVLPFTHT NGARLKLSKAKDQYRLLYRELEQLIQLNATTMHHKNLLESLQSLRAAYGDAPLKSEPGASLLRSFTESPLSPERLEPISSVGASGSSNSNSLLKASKRRMSSCGQRSLLDIISSAERSQSNKRLDFSGRL CTPLGQVAKLYPEFGTKDKDAVTTGASITPNVKEESVRS

Subcellular Location

Description
Nucleus {By SimilarityUniProtKB:Q9VEX5}. Cytoplasm {By SimilarityUniProtKB:Q9VEX5}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q9VEX5}. Note=Colocalizes with dynein-dynactin on the nuclear surface at the meiotic G2/prophase transition in primary spermatocytes. Nuclear location is required for recruitment of dynein motors to nuclear envelope at G2/M. {By SimilarityUniProtKB:Q9VEX5}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Integrator Complex (GO:0032039) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Plays a role as a regulator of spermatogenesis. Crucial regulator of the mitotic cell cycle and development. Required for the correct dynein-dynactin perinuclear localization important for nucleus- centrosome coupling that occur upon meiotic progression of primary spermatocytes. Crucial regulator of the mitotic cell cycle and development. Plays a role in sperm motility and fertility. May have a role in the PNG/PLU/GNU pathway (By similarity). {By SimilarityUniProtKB:Q9VEX5}.
Assigned Ontology terms

Biological Process	Cell Division (GO:0051301) Centrosome Localization (GO:0051642) Dorsal Appendage Formation (GO:0046843) Flagellated Sperm Motility (GO:0030317) Meiotic Cell Cycle (GO:0051321) Oocyte Nucleus Localization Involved In Oocyte Dorsal/Ventral Axis Specification (GO:0051663) Posterior MRNA Localization Involved In Anterior/Posterior Axis Specification (GO:0060814) Regulation Of Fertilization (GO:0080154) Regulation Of Mitotic Cell Cycle (GO:0007346) SnRNA 3'-End Processing (GO:0034472) Spermatogenesis (GO:0007283)
Molecular Function

Cross-References

Database	Links
UNIPROT	B4QX59
Pfam	PF10221

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