NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

F-box/LRR-repeat protein 5 - Salmo salar - NucEnvDB

F-box/LRR-repeat protein 5 (Salmo salar)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	F-box/LRR-repeat protein 5
Accession Code	C0HAC0
Gene	fbxl5
Organism	Salmo salar \| Atlantic salmon (Taxonomy: 8030)
Part of Reference Proteome?	Yes
Sequence (Length: 696)
MAPFPDEVDVFTGPHWRMKQLVGLYCEKLSQTNFSNNNDFRSFLQSLCATFKEFKMHEQIENEYIIGLLQQRSCNVYNVHSDNKLSEMLSLFEKGLRSVKSENEQLNYAQQLKERLEAFTQDFLPHMKEE EEVFQPMLMQYFTYEELKDIKKQVIAQHSSQQRWDCAAEVLKGLSLWSQAEELHKAFKYADHEKTDDELEKELCSTHISQLPTEILLCLFRYLGPEDLCHCGQVCSAWSDLAKTGSLWRHLYPVRWARGD YYRGPPDDVNQEPDEEWVKSLQDEGKAYQEWDEDADVDESDASCEDSLAISAAQREKKLLNGMIQNLLPAVGSSVRSIVLAYSSTVSSKMVRQILSLCPNLTHLDLTQTDVTDSAFDSWSSLWACLSLEH LDLSGCEKLTDRTLKKLSLGLGDLASPTCSEKRSDRRAKLLKSPPSPISLLDKRSLRPTGHSRQVLIFKQWPGKLGSAPCSPTRVWVLDASELADIEDAAEWNRRRGVSTPEVRGFVETQPGGLSCCCRR RRGGFRTGFSTSYWQQQYGLGEAGCGHSTCCTGETALRTLGGLQYESYTTRGSAGAEFRTKCSSGGQLCLECDNRTDPSDGRRSLRFLSLSGCYQVTDLGLRALSQRGGLPLLEHLNLSGCLLITEVGLQ ELVSACPALNDEHFYYCDNINGPHADTASGCQNLQCGFRVCCRSGE

Subcellular Location

Description
Cytoplasm, perinuclear region {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Perinuclear Region Of Cytoplasm (GO:0048471) SCF Ubiquitin Ligase Complex (GO:0019005)

Biology & Function

Description
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of ireb2/irp2. Upon high iron and oxygen level, it specifically recognizes and binds ireb2/irp2, promoting its ubiquitination and degradation by the proteasome (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Iron Ion Homeostasis (GO:0055072) Protein Ubiquitination (GO:0016567) SCF-Dependent Proteasomal Ubiquitin-Dependent Protein Catabolic Process (GO:0031146)
Molecular Function	Iron Ion Binding (GO:0005506)

Cross-References

Database	Links
UNIPROT	C0HAC0
Pfam	PF12937 PF01814 PF13516
PROSITE	PS50181

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK