NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Myelin-associated neurite-outgrowth inhibitor - Rattus norvegicus - NucEnvDB

Myelin-associated neurite-outgrowth inhibitor (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Myelin-associated neurite-outgrowth inhibitor
Accession Code	D4AEP3
Gene	Fam168b
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 194)
MNPVYSPGSSGVPYANAKGIGYPAGFPVGYAAAPAYSPNMYPGANPTFQTGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQQGTYYTQPLYAAPPHVIHHTTVVQPNGMPATV YPAPIPPPRGSGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYVPPQW

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:22771904}. Cell membrane {Experimental EvidencePubMed:22771904}; Multi-pass membrane protein {Experimental EvidencePubMed:22771904}. Cell projection, axon {Experimental EvidencePubMed:22771904}. Note=In cortical neurons, predominantly found at perinuclear regions. Expressed in neuronal cell bodies and axonal fibers. {Experimental EvidencePubMed:22771904}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Axon (GO:0030424) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27. {Experimental EvidencePubMed:20716133}.
Assigned Ontology terms

Biological Process
Molecular Function

Protein-Protein Interactions

Interactions with other proteins (4 interactors)

Partner (UniProt)		IntAct	Confidence score
Q92567	Protein FAM168A (Tongue cancer chemotherapy resistance-associated protein 1)	EBI-7957948	0.37
Q96QA6	Protein yippee-like 2	EBI-7958149	0.37
Q15038	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2) (Proline-rich transcript in brain protein)	EBI-7958079	0.37
Q8IUR5	Protein O-mannosyl-transferase TMTC1 (EC 2.4.1.109) (Transmembrane and TPR repeat-containing protein 1)	EBI-7958221	0.37

Cross-References

Database	Links
UNIPROT	D4AEP3
Pfam	PF14944

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