NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein unc-45 homolog B - Xenopus tropicalis - NucEnvDB

Protein unc-45 homolog B (Xenopus tropicalis)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Protein unc-45 homolog B
Accession Code	D7REX8
Gene	unc45b
Organism	Xenopus tropicalis \| Tropical clawed frog (Taxonomy: 8364)
Part of Reference Proteome?	Yes
Sequence (Length: 927)
MEDPVQLKEEGNKYFQSNEYGQAIQCYSKALKLITDKKMQAVLYRNRSACYLKQDNYVQAAADASKAIDVDASDIKALFRRCQALEKLGKLDQAYKDVQRCATLEPKNRTFLETLHRLGTNIQEKLHVQF STDSRVHKMFEILLDKNSEKEKREKAANNLIVLGREDAGAEQIFQNNGVNLLMQLIESKDPEMILSAIRTLSGMCTGHRARATAIVHLVGINKICSIMAVDNEEIALAACNLLQNIVDSLTGEDKKAHGK QEALVLDTKKDLKIITTHLLDMLVSKKVSGHGRDQALNLLNKNIPRYDLKNKDNSKSLFVVDAGLKKILKVLGQVPELPNCLPLTPNTRLNASVLVNKLYDDLRCDPERDNFRIICEEYITGSFDPKDME KNLHAIQTVSGILQGPFDLGNKLLSLQGVMEMMVALTGSENEVDQLVAVEALIHASTKLSRASFIITNGVSLLKDIYKKTKNEKIKIRALVGLCKLGSAGGTDYALRQFAEGSTDKLAKQCRKWLCNPSL DIQTRKWAVEGLAYLTLDADVKDEFVEDEQSLKAMFELSKTSDKTILYSVATTLVNCTNSYDVKEVIPEMVQLAKFSKQHVPEQHPKDKKDFVEKRVKRLLKADVISALSCMVKADNSILTDQTKEQLSR VFLALCEDPKDRGIIVAQGGGKAMIPLALEGTDVGKIKASHGLAKIAAVSNPDIAFPGERVYEVVRPLVSLLNTERDGIQNFEALLALTNLSGKNDKLRQKIIKEKALPEIENYMFENHEQIRQAATECM CNLALNKEVKERFMAEGNDRLKLIILLCGEEDEVKLQRAAAGTLAMLTGAEKKLCHKMTEVTTQWMEILQRLCLSEDLQVQHRGVVIAYNLINADKELAKKLVESEMLEILTVIGKQADVPNKQHIINAA REALVKCLDYGFIKTVS

Subcellular Location

Description
Cytoplasm, myofibril, sarcomere, Z line {By SimilarityUniProtKB:Q6DGE9}. Cytoplasm, myofibril, sarcomere, A band {By SimilarityUniProtKB:Q8IWX7}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q6DGE9}. Cytoplasm, cytosol {ECO:0000250\|UniProtKB:Q8CGY6}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage. {By SimilarityUniProtKB:Q6DGE9}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	A Band (GO:0031672) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Perinuclear Region Of Cytoplasm (GO:0048471) Z Disc (GO:0030018)

Biology & Function

Description
Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development. {By SimilarityUniProtKB:Q6DGE9, By SimilarityUniProtKB:Q8CGY6, Experimental EvidencePubMed:20637071}.
Assigned Ontology terms

Biological Process	Cell Differentiation (GO:0030154) Chaperone-Mediated Protein Folding (GO:0061077) Lens Development In Camera-Type Eye (GO:0002088) Muscle Organ Development (GO:0007517)
Molecular Function	Hsp90 Protein Binding (GO:0051879)

Cross-References

Database	Links
UNIPROT	D7REX8 Q68ER3
Pfam	PF11701
PROSITE	PS50005 PS50293

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