NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

NFX1-type zinc finger-containing protein 1 homolog - Caenorhabditis elegans - NucEnvDB

NFX1-type zinc finger-containing protein 1 homolog (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	NFX1-type zinc finger-containing protein 1 homolog
Accession Code	E9P860
Gene	znfx
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 2443)
MSRDKPPQREVGGRRLPYEMGSLKFDEDPFRGQRRRPWMCFRIGYPTSEFSSEHFMKFVKRCHTSMIEVGILLDDEREFLQYQEVREDYLLLKKLIEEGLQKCETIYEKGPLSTPVVFFILDQCDEDEVQ NMLDMFRESCYIFHMKRNEILNWINEMEYEELESDCSKFAQFIKGVENLTESIAMPMEVETEEFIFGKSSIVSTEDFVEDAPHKQIAQDQRETRPIRQPYSMVRNLAPPGLPPPGISISNSSPPGLSSVS PIPRADTRESRYSTPQPPGLSIPAPPGISLPTPPGISLQNHQNDQFEQAHSTISRMSENSSSSRRRFRDEEVQEEEGDHILSSEDVHAARNVCETKILVRGVPQKNDSELSKLINGSKLYVRFERPFVKL AHNLELLYVVNYAISSRKSIVRDHSKAIIRGLFEKDFLLKLKSKFLESSFDNDTWTPEGTELLFEIFHLFFTTARYKGGFMLTLPRFAPSWHDFSMAFDIADMDGLEEAGVGDDELRNLRRLIGYIETWI KRAERERNPSPLALRSYSVYEKAGSSDSGRQVLSESRGAGSSNVYGHDEVDFVDHRRRDEFGHRDNYRTENRRHKSPDNFGEVHRRLDEQQQQRHEDESSRYRDDSRQSRRADDRRDQYQYNESTSMENH LGFHNGGGTVSEHSRDDKFVSPQNCEEKRKYCEEDTDAKPQQPYRFEEIKFEPIWVKCEKSEPPEDFKTLPSVPVLSEYVNPVEPYLRRIQDDGKYKSVHHYLDVQFRLLKEDLVSPLRDGIDLYKKNGT CKGRRIEGAPCSDISIFNVEKVDGKQVTERDGYEMRIIWPAQYDILKLLDNDREMKELGLVMLSCDRFKEDFHLGHIQSSYLMRNGSLHFAVHEETSPFKPNTTYQMAQGTSYLPCYKHVLENLKRISSF KPLPFERYLVHGSKIIFRPNFQQAEKSEYQISEEKKLMKTYNELRSLAACARYTKGKPIPRGVDDDDEDYEFSKSRELSKEDIDLEYRQLQEPIFRPLVGVDIKDSNLIQINKKWYNVSRLLDEFHPDYM DESQRLAFCNTFKYELSLIQGPPGTGKTHIGVQIVKTILQNRSYWKITEPILVVCFTNSGLDNLLERIYQMIENDEELSKDNGRPKIIRFGSKCDSNYLKRQNVMRQDVYEQYKSKVSDGAQKKMSKAGA ARRHKADNLAISSYTLFCSRNKLLSYEMLSRVMDPNHQMEIQQFTYDHVDTKGIPLSPDEAIGCWLLERDFGKATKSQTKKAKKPKFQGAQLDSEDENKDYFTVEDSDDEEDELDDEKLLDKLFEKMNLE CSGADILSAVHASHADEYYTKGPWEIVQDKRPSVVVLMEKKTKPCNAKFTVDEQINNLVSEIKDMILSSQPVPKKDLNDIKYIFSLARLKRWSLYITWCDALRSIVTENLPRQIREYREACENFKNAQNR VDAEIMRMTMIIGATTTGCSRLRPTLEKVGPRILIVEEAAEVLEAHIISAMISTVEHVVMIGDHKQLRPNPAVHELGVAYGLRISMFERLVERGLPFSQLRQQHRMNLTISDKIVKLSFYDNVTDAENVG LYPDVQGMATNLFFWSHTSMEESPDEVSWLNKHEISMTVALVKHLLKQNYTTNDIVVLATYSAQKNLMYREYANVFGSTPDSNVIPVETVDSFQGKERKIVIVSLVRSHRGGRENTGIGFLAVANRICVA LTRAQHGMYIIGNGAYIMNNSELWNKIVNNLRRSNLIEYNLPLKCVAHGNIVTVKDPQDFATKSPEGGCMQKCDTKKFCGHVCERLCHPNMEEEHLQRCLYNCDKKCSNPQFQHRCKKACYEECGSCLYL VEVTLDCGHRITTPCSRINSSKCDQSCTKKLLCGHACAAKCGEECTLVSECSQLVGMPLSCGHIKQLTCSKISANEIDLTCDQRCEKTMLACPHKCAEICGQPCTVECMEVVNVTLGCSHSQDVVCSSFM PGMTDHIECLTKVPKTLSPCKHTELVLCKQAPSTKLCTRRCTSYLEKCGHTCENDCGICFTTKTHICQNMCQKVLNCGHTCSAKCGESCPPCKAFCTNKCEHQSCGAGERGFGRDCSKLCALCVNNCSNK CAHRSCTLKCFEECNVKPCTEPCTDKLKCGHACLGICGEQCPKICGTCERNKYIECVSGTSSTSRVHRLIMIPKCYHVFPVEVLDDHVKKQKEANEKLKCPKCSAFIVGVLRYARYTKKYYLNENMRKLE SNIRNIHQSTLEGRVFQAVQDSIGEIRNVTTNLTNASEDILRNFHQKILDIRTSAETFKGKPEHKFKFASLLQVANCCLAITRLLSVSSKFRVSRRKDIPPTFDLMSVRVLGDMPFPKLIDELNRVNIHL SNTYETFMPGAIIPKLKWLISRMTVLQQLTSMCHQLVLEKKDIADSDAHAINDACLNMFRYNEQHNYALNIENFEAIVVKVAPKLLEPTPKFWSWRRLQVPEL

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:29769721, Experimental EvidencePubMed:29775580}. Cytoplasm {Experimental EvidencePubMed:29775580}. Cytoplasmic granule {Experimental EvidencePubMed:29769721, Experimental EvidencePubMed:29775580, ECO:0000269\|PubMed:32843637}. Note=Co-localizes with wago-4 in P- granules in germline blastomeres until the 100-cell stage (PubMed:29769721). During oocyte maturation, co-localizes with wago-4 in liquid-like condensates in the cytoplasm called Z granules (PubMed:29769721). Localizes to perinuclear and cytoplasmic P-granules in germline blastomeres and germ cells (PubMed:29775580, PubMed:29769721). In the adult germline, co-localizes with deps-1 in P- granules (PubMed:32843637). {Experimental EvidencePubMed:29769721, Experimental EvidencePubMed:29775580, ECO:0000269\|PubMed:32843637}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Nuclear RNA-Directed RNA Polymerase Complex (GO:0031380) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Epigenetic inheritance factor which, in association with the Argonaute protein wago-4, mediates small RNA-directed transgenerational epigenetic inheritance and thus balances the transgenerational inheritance of epigenetic information (PubMed:29775580, PubMed:29769721). Specifically, maintains a balanced production of small RNAs by preventing the spread of epigenetic signals towards the 5'-end of target mRNAs (PubMed:29775580). Plays a role in small RNA- induced gene silencing in the germline (PubMed:29775580). {Experimental EvidencePubMed:29769721, Experimental EvidencePubMed:29775580}.
Assigned Ontology terms

Biological Process	RNA-Mediated Gene Silencing (GO:0031047) RNA-Mediated Heterochromatin Formation (GO:0031048)
Molecular Function	ATP Binding (GO:0005524) ATP Hydrolysis Activity (GO:0016887) RNA Binding (GO:0003723) RNA Helicase Activity (GO:0003724) Zinc Ion Binding (GO:0008270)

Cross-References

Database	Links
UNIPROT	E9P860 Q23388
Pfam	PF13086 PF13087

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