NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Regulator of nonsense transcripts 1 - Danio rerio - NucEnvDB

Regulator of nonsense transcripts 1 (Danio rerio)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Regulator of nonsense transcripts 1
Accession Code	F1RCY6
Gene	upf1
Organism	Danio rerio \| Zebrafish (Taxonomy: 7955)
Part of Reference Proteome?	Yes
Sequence (Length: 1100)
MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTQGQTQSQLDNQVNGPDGVLPNGEDAVGKTSQLLAELNFEEDEEDTYYTKDLPVHACSYCGIHDPACVVYCNTSKKWFCNGRGNT SGSHIVNHLVRAKCKEVTLHKDGPLGETVLECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLEELWKENPTATLEDLE KPGVDEEPQHVLLRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGDMRLMQGDEICLRYKGDMAPLWKGIGHVIKVPDNYGDEIAIELRSSAGAPVEVPHNFQ VDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGLK VVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSSSDEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVV MCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRLKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTRLLKAGAKPDQIGIITPYEGQR SYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFM STAMYDAREAMIPGSVYDRSSTGRPSNMYFQTHDQVGMIGTGPNPMGSLNIPIPFNLVMPPMPPPGYLGQVNGPAAGRGAPKGKTGGRGGRQRNRGTGNHGSGQPNMPNSQASQDLVSQPFSQGPLTQGY ITMSQPSQMSQPGLSQPELSQDSYLGDEFKSQMDVALSQDSTYQGERAYQHGGVTGLSQY

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q9EPU0}. Cytoplasm, P-body {By SimilarityUniProtKB:Q92900}. Nucleus {By SimilarityUniProtKB:Q92900}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q9EPU0}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Nucleus (GO:0005634) P-Body (GO:0000932) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an upf1-upf2-upf3 surveillance complex is believed to activate NMD. {By SimilarityUniProtKB:Q92900}.
Assigned Ontology terms

Biological Process	Chordate Embryonic Development (GO:0043009) Nuclear-Transcribed MRNA Catabolic Process (GO:0000956) Nuclear-Transcribed MRNA Catabolic Process, Nonsense-Mediated Decay (GO:0000184)
Molecular Function	ATP Binding (GO:0005524) DNA Binding (GO:0003677) Hydrolase Activity (GO:0016787) RNA Binding (GO:0003723) RNA Helicase Activity (GO:0003724) Zinc Ion Binding (GO:0008270)

Cross-References

Database	Links
UNIPROT	F1RCY6 A0A0R4IY20 Q7ZVZ4
Pfam	PF13086 PF13087 PF04851 PF18141 PF09416
PROSITE	PS51997

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