NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Suppressor of RPS4-RLD 1 - Arabidopsis thaliana - NucEnvDB

Suppressor of RPS4-RLD 1 (Arabidopsis thaliana)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Suppressor of RPS4-RLD 1
Accession Code	F4JS25
Gene	SRFR1
Organism	Arabidopsis thaliana \| Thale cress (Taxonomy: 3702)
Part of Reference Proteome?	Yes
Sequence (Length: 1052)
MATATATSERFELAKHCSSRNWSKAIRVLDSLLAKESSILDICNRAFCYNQLELHKHVIKDCDKALLLEPFAIQAFILKGRALLALGRKQEAVLVLEQGYKSALQQTADVKQLLELEELLKDARREIDGI LKSHATESPQETPAYHSEKSDEKSDKLDNHESGASSNGNSHESSSELGEQSKIVSFSKVASKASKQSDGNSDLCNGSVYKEKENGKCGSQINGYYESCKPCNGSDLHDNLAESSDRFGELSINGNKISIK SSKMSHKAEARCGISDESRKNKKYTIARISGTHSISVDFRLSRGIAQVNEGNYTKAISIFDKVLKEEPTYPEALIGRGTAYAFQRELESAIADFTKAIQSNPAASEAWKRRGQARAALGEYVEAVEDLTK ALVFEPNSPDVLHERGIVNFKSKDFTAAVKDLSICLKQEKDNKSAYTYLGLAFASLGEYKKAEEAHLKSIQLDSNYLEAWLHLAQFYQELADHCKALECIEQVLQVDNRVWKAYHLRGLVFHGLGEHRKA IQELSIGLSIENTIECLYLRGSCYHAVGEYRDAVKDYDATVDVELDAVEKFVLQCLAFYQKELALYTASKVSSEFLCFDIDGDIDPMFKEYWCKRLHPKNVCEKVYRQPPLRESLKKGKLKKQDLAITKQ KANILRFADLIGKRIQYDCPGFLPNKRQHRMAGLAVIEIAQKVSKAWRIEWRNSTKGTTKNGKKNRRRERTNILSQNRGGAGCSSSSFSETSTGYASLEDRSSGRSILSWQDVYSPAVRWRQISEPCDPV VWVNKLSEEFNSGFGSHTPMVLGQAKVVRYFPNYERTLTLAKSIIKDKLSVRSKKDKVIDLSKDEKIEKIMRAETCDELHNIVGEDFWVATWCDSTGSEGKRLEGTRITCIQKPGRLGYDFSIRTPCTPA RWSDFDEEMTSAWEALCTAYCGENYGSTELDALETVRDAILRMTYYWYNFMPLARGTAVTGFVVLLGLLLAANMEFTETIPKGLQIDWEAILNVEPGSFVDSVKSWLYPSLKINTSWRDHTEISSAFSTT GAVVAALSTYND

Subcellular Location

Description
Nucleus {Experimental EvidencePubMed:18774967, Experimental EvidencePubMed:21079790}. Cytoplasm {Experimental EvidencePubMed:18774967}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:18774967}. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Microsome {Experimental EvidencePubMed:21079790}. Note=Found in microsomes when interacting with SNC1 and RPS4. {Experimental EvidencePubMed:21079790}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Endoplasmic Reticulum (GO:0005783) Intracellular Membrane-Bounded Organelle (GO:0043231) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Negative regulator of effector-triggered immunity associated with the EDS1 resistance pathway (PubMed:15469494, PubMed:18774967, PubMed:19649196, PubMed:19525323, PubMed:20862316, PubMed:21079790). May localize its interactors to a microsomal membrane (PubMed:22158819). May therefore negatively regulate RPS4 and SNC1 translocation to the nucleus (PubMed:21079790). Contributes to the regulation of RPS2 and RPS4 protein levels and negatively regulates SNC1 stability (PubMed:20862316). {Experimental EvidencePubMed:15469494, Experimental EvidencePubMed:18774967, Experimental EvidencePubMed:19525323, Experimental EvidencePubMed:19649196, Experimental EvidencePubMed:20862316, Experimental EvidencePubMed:21079790, Experimental EvidencePubMed:22158819}.
Assigned Ontology terms

Biological Process	Defense Response To Bacterium (GO:0042742) Negative Regulation Of Defense Response (GO:0031348) Negative Regulation Of DNA-Templated Transcription (GO:0045892)
Molecular Function	Molecular Adaptor Activity (GO:0060090)

Protein-Protein Interactions

Interactions with other proteins (3 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9FPR2	Lysine-rich arabinogalactan protein 18 (Lys-rich AGP 18)	EBI-4481445	0.44
Q9SUR9	Protein SGT1 homolog A (AtSGT1a) (Suppressor of G2 allele of SKP1 homolog A)	EBI-4498032	0.37
Q9SUT5	Protein SGT1 homolog B (AtSGT1b) (Protein ENHANCED DOWNY MILDEW 1) (Protein ENHANCER OF TIR1-1 AUXIN RESISTANCE 3) (Suppressor of G2 allele of SKP1 homolog B)	EBI-4498040	0.37

Cross-References

Database	Links
UNIPROT	F4JS25 Q8GYX1 Q9SZU6
Pfam	PF13181
PROSITE	PS50005 PS50293

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK