National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | Nuclear egress protein 1 |
| Accession Code | F5H982 |
| Gene | NEC1 |
| Organism | Human herpesvirus 8 strain GK18 (Taxonomy: 868565) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 302) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Host Nuclear Envelope | SL-0415 | The host nuclear envelope is a membrane system which surrounds the host nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the host nuclear intermembrane space. Note: This location is defined for viral proteins that appear in the Nuclear Envelope of infected host cells |
| Host Nuclear Membrane | SL-0418 | The membrane surrounding the host nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer host nuclear membrane. Note: This location is defined for viral proteins that appear in the Nuclear Membrane of infected host cells |
| Host Nuclear Inner Membrane | SL-0419 | The inner membrane surrounding the host nucleus is the membrane which separates the host nuclear matrix from the host intermembrane space. Note: This location is defined for viral proteins that appear in the Nuclear Inner Membrane of infected host cells | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
|
|---|---|
| Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network. {Sequence AnalysisHAMAP-Rule:MF_04023, Experimental EvidencePubMed:23365436}. | Assigned Ontology terms |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory