NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

UBX domain-containing protein 3 - Caenorhabditis elegans - NucEnvDB

UBX domain-containing protein 3 (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	UBX domain-containing protein 3
Accession Code	H2L056
Gene	ubxn
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 613)
MDLTASLEDDQREKLRQYTEFTHQQDYEVAIGTLASLNWNLEQAIEAHLMQEDKNDDEDPEILETIPAAASGRNAGASSSSRFEPEVINIEDDEMPATRGRRRGRAVTPDETTTVDNQVKRLRIDDGSSS SSNGAATHHRGAAIPRQKRGQATEPTPSSSGSSSASFSSRRGTRANPVPPPNQEPAHPESARQNGGILASRHNNHNNQQNNHHHHHQRIPINPRRVDVFNVDSDEDDDSMAIAYEDDDDGVHEVHHSEVV ARGSGPPNGRIPMIPDGFSSVSDALRNFVAIFSDRFCSTPQTQAFMPPFYTEPLPAAVKEAFDHPNSEHRRPLLFYINHDRSIAANIFASQVLCSETVSTLIRHQYVLFPWDITSDSNLMLFLEYLQAAN MGDVRTIIQRLAMSKIESFPLMAIVVKERNSYRLVDYCRGTDTSDQVMEKLLSGVSEYSDIRMNEQSERREREEREAIRNQQEAEYKASLAADKARMEAKQQEIEEQRLEEERKLREEEEECVRRQTVAS TVPEEPPASAPLAEIINVKFRLPEGGQDMRRFRRLESIQTLINYLSSKGYSPDKFKYFNSDFPKKEITRHFDLSHNFADTKWPAREQIFVEEI

Subcellular Location

Description
Nucleus {Experimental EvidencePubMed:26842564}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:20977550}. Chromosome {Experimental EvidencePubMed:26842564}. Cytoplasm {Experimental EvidencePubMed:26842564}. Note=Colocalizes with cdc-48.1 to the perinuclear region in spermatocytes (PubMed:20977550). Localizes to the nucleus during S phase in a cdc-48 and npl-4-dependent manner (PubMed:26842564). {Experimental EvidencePubMed:20977550, Experimental EvidencePubMed:26842564}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Chromatin (GO:0000785) Cytoplasm (GO:0005737) Endoplasmic Reticulum (GO:0005783) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity (PubMed:20977550, PubMed:26842564, PubMed:28368371). Together with ubxn-1 and ubxn-2, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1 (PubMed:20977550). During mitosis, ensures the degradation of DNA licensing factor cdt-1 and the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:26842564, PubMed:28368371). {Experimental EvidencePubMed:20977550, Experimental EvidencePubMed:26842564, Experimental EvidencePubMed:28368371}.
Assigned Ontology terms

Biological Process	Cell Differentiation (GO:0030154) Masculinization Of Hermaphroditic Germ-Line (GO:0042006) Positive Regulation Of Mitotic Cell Cycle, Embryonic (GO:0045977) Positive Regulation Of Protein Catabolic Process (GO:0045732) Regulation Of Protein Localization To Chromatin (GO:1905634) Spermatogenesis (GO:0007283) Ubiquitin-Dependent ERAD Pathway (GO:0030433)
Molecular Function	K48-Linked Polyubiquitin Modification-Dependent Protein Binding (GO:0036435) Protein-Containing Complex Binding (GO:0044877) Ubiquitin Binding (GO:0043130)

Cross-References

Database	Links
UNIPROT	H2L056 A0A0K3ARL0 A0A0K3ATZ0 A0A0K3AWX1 Q6A589
PROSITE	PS50033

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