NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Mitogen-activated protein kinase kinase kinase 4 - Mus musculus - NucEnvDB

Mitogen-activated protein kinase kinase kinase 4 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Mitogen-activated protein kinase kinase kinase 4
Accession Code	O08648
Gene	Map3k4
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1597)
MRDAIAEPVPPPALADTPAAAMEELRPAPPPQPEPDPECCPAARQECMLGESARKSMESDPEDFSDETNTETLYGTSPPSTPRQMKRLSAKHQRNSAGRPASRSNLKEKMNTPSQSPHKDLGKGVETVEE YSYKQEKKIRATLRTTERDHKKNAQCSFMLDSVAGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSMPMPIARTARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTAAFWFNRSNELIWLE LQAWHAGRTINDQDLFLYTARQAIPDIINEILTFKVNYGSIAFSSNGAGFNGPLVEGQCRTPQETNRVGCSSYHEHLQRQRVSFEQVKRIMELLEYMEALYPSLQALQKDYERYAAKDFEDRVQALCLWL NITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGYEPEDEVEDTEVELRELESGTEESDEEPTPSPRVPELRLSTDAILDSRSQGCVSRKLERLESEEDSIGWGTADCGPEASRHCLTSIYRPF VDKALKQMGLRKLILRLHKLMNGSLQRARVALVKDDRPVEFSDFPGPMWGSDYVQLSGTPPSSEQKCSAVSWEELRAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVL KGGLLMKQYYQFMLQEVLGGLEKTDCNMDAFEEDLQKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLESGLQESCAELWTSADDNGAADE LRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFVLSASARELLDALKAKQYVKVQIPGLENLHVFVPDSLAEEKKIILQLLNAATGKDCSKDPDDVFMDAFLLLTKHGDRARDSEDGWGT WEARAVKIVPQVETVDTLRSMQVDNLLLVVMESAHLVLQRKAFQQSIEGLMTVRHEQTSSQPIIAKGLQQLKNDALELCNRISDAIDRVDHMFTLEFDAEVEESESATLQQYYREAMIQGYNFGFEYHKE VVRLMSGEFRQKIGDKYISFAQKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFSTRSVPSDA RTHGNSVAAAAAVAAAATTAAGRPGPGGGDSVPAKPVNTAPDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYPRSDSSGSTRRSWELRTLISQTKDSASKQGPIEAIQKSVRLFEERRYRE MRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIR LYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLS PEGKAFLSHCLESDPKIRWTASQLLDHAFVKVCTDEE

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:16157600}. Note=Localized in perinuclear vesicular- like structures, probably Golgi-associated vesicles.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {Experimental EvidencePubMed:16157600, Experimental EvidencePubMed:9079650}.
Assigned Ontology terms

Biological Process	Chorionic Trophoblast Cell Differentiation (GO:0060718) Determination Of Dorsal Identity (GO:0048263) Intracellular Signal Transduction (GO:0035556) Male Germ-Line Sex Determination (GO:0019100) MAPK Cascade (GO:0000165) Placenta Development (GO:0001890) Positive Regulation Of JUN Kinase Activity (GO:0043507) Positive Regulation Of P38MAPK Cascade (GO:1900745) Positive Regulation Of Telomerase Activity (GO:0051973) Positive Regulation Of Telomere Capping (GO:1904355) Positive Regulation Of Telomere Maintenance Via Telomerase (GO:0032212) Protein Phosphorylation (GO:0006468) Regulation Of Gene Expression (GO:0010468) Response To UV-C (GO:0010225)
Molecular Function	ATP Binding (GO:0005524) MAP Kinase Kinase Kinase Activity (GO:0004709) Metal Ion Binding (GO:0046872) Protein Kinase Activity (GO:0004672) Protein Serine Kinase Activity (GO:0106310)

Cross-References

Database	Links
UNIPROT	O08648 O08649 O70124 Q6PDG6
Pfam	PF19431 PF00069
PROSITE	PS00107 PS50011 PS00108

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