NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Phospholipase D1 - Cricetulus griseus - NucEnvDB

Phospholipase D1 (Cricetulus griseus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Phospholipase D1
Accession Code	O08684
Gene	PLD1
Organism	Cricetulus griseus \| Chinese hamster (Taxonomy: 10029)
Part of Reference Proteome?	No
Sequence (Length: 1036)
MSLKSEHRVNTSALQKIAADMSNLIDNLDTRELHFEGEEVEFDTSPGDPKAQEKYIPFSSIYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFTWQVKRKFKHFQEFHREL LKYKAFIRIPIPTKRHTFRRQNVKEEPREMPSLPRSSENTIQEEQFFGRRKQLEDYLTKILKMPMYRNYHATTEFLDVSQLSFIHDLGPKGLEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDS FLLYMKPDSGAIAFVLLVDKEFRIKVGRKETETKYGLRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGSDFLKDHRFGSYAAVHENMLAKWYVNAKGYFEDIANAMEEAAEEIFITDWWLSPEIFLK RPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYSKRTLMRLHPNIKVMRHPDHVSSSVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGLSMGSLAAATMESM ESLSLKDNHRSHKNEPILKSVDDVDPKLKGVGKPRKFSKFSLYRQLHRRHLHNSDSVSSIDSASNTGSIRSVQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRIPWHDIGSVLHGK AARDVARHFIQRWNFTKIMKPKYRSLSYPFLLPKSQSTAHELRYQVPGAVPAKVQLLRSAADWSAGIKHHEESIHSAYINVIENSKHYIYIENQFFISCADDKVVFNKVGDAIAQRILKAHREGQRYRVY IVIPRLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKPELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSIMDGKEYQA GCFAQGLRLQCFRLVLGYLSDPSEDLQDPVSDKFFKEIWVSTAARNATIYDKVFRCLPNDEVHNLMQLRDFISKPILAKDDPIRAEEELRKIRGFLVQFPFYFLSEENLLPSVGTKEAIVPMEVWT

Subcellular Location

Description
Cytoplasm, perinuclear region {By Similarity}. Endoplasmic reticulum membrane {By Similarity}; Lipid-anchor {By Similarity}; Cytoplasmic side {By Similarity}. Golgi apparatus membrane {By Similarity}; Lipid-anchor {By Similarity}; Cytoplasmic side {By Similarity}. Late endosome membrane {By Similarity}; Lipid-anchor {By Similarity}; Cytoplasmic side {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	By Similarity {ECO:0000250}
Assigned Ontology terms

Cellular Component	Endoplasmic Reticulum Membrane (GO:0005789) Golgi Membrane (GO:0000139) Late Endosome Membrane (GO:0031902) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Inositol Lipid-Mediated Signaling (GO:0048017) Lipid Catabolic Process (GO:0016042) Phosphatidic Acid Biosynthetic Process (GO:0006654)
Molecular Function	N-Acylphosphatidylethanolamine-Specific Phospholipase D Activity (GO:0070290) Phosphatidylinositol Binding (GO:0035091) Phospholipase D Activity (GO:0004630)

Cross-References

Database	Links
UNIPROT	O08684
Pfam	PF00169 PF00614 PF13091 PF00787
PROSITE	PS50035 PS50195

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