NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Nuclear cap-binding protein subunit 1 - Schizosaccharomyces pombe 972h- - NucEnvDB

Nuclear cap-binding protein subunit 1 (Schizosaccharomyces pombe 972h-)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Nuclear cap-binding protein subunit 1
Accession Code	O14253
Gene	cbc1
Organism	Schizosaccharomyces pombe 972h- (Taxonomy: 284812)
Part of Reference Proteome?	Yes
Sequence (Length: 780)
MSSYRGSTRPRKRTREGENYGFRPHRGNSQELLAARIKKDITFLADPRGNSVAADDINYVAMSLSREANDPETISTILDCIQTTAFIIPVKIPHLATLIIRASLRVPLILEKAAAYFCLQYFTNLNSFLY YEAKVDLRMLICMSFALQPGTLKPLFSLLADAISKETKPSVWGDNFLRIILINLPYFIAANNDLGKKDFANEILDQCEIYVRHRKSSITLSNPLSIHDNLSEEELDLLYKQLILSRENDFTFPYISQPWK FFESDFVHIVPVSPSIPEWTFQPTPQQNELPSFKRFFELFNNFEIRTTPDASDVAASIFRDISVDVINHLEFNRVEAAQVLTDLDVYFTYKTFALRGTPVNELPNLDPSESRWKAEDIIVEAVLGELLGS QNTTYKPVYYHSLLIECCRIAPKILAPTFGRVIRLMYTMSSDLPLQTLDRFIDWFSHHLSNFNFHWKWNEWIPDVELDDLHPKKVFMRETITRELILSYYTRISDSLPEELRCLLGEQPSGPNFVYENET HPLYQQSSQIIEALRLHKPLEELDIILQSEEIQNSETSAVRLVMSCAYSLGSRSFSHALNVFEKHLNTLKHFSRKSLDSEIEVVDELFSFWKLQPFNAVMWLDKMLNYSIISITSIIEWLIKQDVTIWSR SYTWSLVNTTFNKLAARLRRSVSNKEDSSLINEANEEKEIVTNLLLSALRALISENAENIWVSHWLNLMLKYVESNFLSVKKDTIEEANEPVQENTSEEQEDTKMQPVDAVDEQPSENNQTAADATNEEK

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:P34160}. Nucleus {Experimental EvidencePubMed:16823372}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Mitotic Spindle (GO:0072686) MRNA Cap Binding Complex (GO:0005845) Nuclear Cap Binding Complex (GO:0005846) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Component of the CBC complex, which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. {By SimilarityUniProtKB:P34160}.
Assigned Ontology terms

Biological Process	MRNA Export From Nucleus (GO:0006406) MRNA Processing (GO:0006397) Nuclear-Transcribed MRNA Catabolic Process, Nonsense-Mediated Decay (GO:0000184) RNA Splicing (GO:0008380)
Molecular Function	MRNA Binding (GO:0003729) RNA 7-Methylguanosine Cap Binding (GO:0000340) RNA Cap Binding (GO:0000339)

Cross-References

Database	Links
UNIPROT	O14253
Pfam	PF02854 PF09088 PF09090

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