NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Atrophin-1 - Mus musculus - NucEnvDB

Atrophin-1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Atrophin-1
Accession Code	O35126
Gene	Atn1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1175)
MKTRQNKDSMSMRSGRKKEAPGPREELRSRGRASPGGVSTSSSDGKAEKSRQTAKKARIEEPSAPKASKQGRSEEISESESEETSAPKKTKTEQELPRPQSPSDLDSLDGRSINDDGSSDPRDIDQDNRS TSPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPPPPDSTPRQPESGFEPHPSVPPTGYHAPMEPPTSRLFQGPPPGAPPTHPQLYPGNASGGVLSGPPMGPKGGAAASSVGAPSGGKQHPPPTT PIPISSSGASGAPPAKPPSAPVGGGSLPSAPPPASFPHVTPNLPPPPALRPLNNASASPPGMGAQPIPGHLPSPHAMGQGMSGLPPGPEKGPTLAPSPHPLPPASSSAPGPPMRYPYSSSSSSAAASSSS SSSSASQYPASQALPSYPHSFPPPTSMSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANNNTHPGPFPPTGGQSTAHPAAPTHHHHQQQPQQQHHHGNSGPPPPGAYPHPLESSNSHHAHPYNMSP SLGSLRPYPPGPAHLPPPHGQVSYNQAGPNGPPVSSSNSSGSSSQASYSCSHPSSSQGPQGASYPFPPVPPVTTSSATLSTVIATVASSPAGYKTASPPGPPQYSKRAPSPGSYKTATPPGYKPGSPPSF RTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSSLSSLPPPPAAPTTGPPLTATQIKQEPAEEYEPPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKK RADLVEKVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYS SDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDPLARLQMLNVTPHHHQHS HIHSHLHLHQQDAIHAASASVHPLIDPLASGSHLTRIPYPAGTLPNPLLPHPLHENEVLRHQLFAAPYRDLPASLSAPMSAAHQLQAMHAQSAELQRLALEQQQWLHAHHPLHSVPLPAQEDYYSHLKKE SDKPL

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:P54258}. Cell junction {By SimilarityUniProtKB:P54258}. Nucleus {By SimilarityUniProtKB:P54258}. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells. Colocalizes with MTG8 in discrete nuclear dots (By similarity). {By SimilarityUniProtKB:P54258}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Cell Leading Edge (GO:0031252) Cytoplasm (GO:0005737) Nuclear Matrix (GO:0016363) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of the poly-Q repeats (By similarity). Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. {By SimilarityUniProtKB:P54259, Experimental EvidencePubMed:16702404, Experimental EvidencePubMed:19131340}.
Assigned Ontology terms

Biological Process	Cell Killing (GO:0001906) Cell Migration (GO:0016477) Determination Of Adult Lifespan (GO:0008340) Maintenance Of Cell Polarity (GO:0030011) Male Gonad Development (GO:0008584) Multicellular Organism Growth (GO:0035264) Negative Regulation Of Transcription By RNA Polymerase II (GO:0000122) Neuron Apoptotic Process (GO:0051402) Post-Embryonic Development (GO:0009791) Regulation Of Neuron Differentiation (GO:0045664) Response To Food (GO:0032094) Spermatogenesis (GO:0007283)
Molecular Function	JUN Kinase Binding (GO:0008432) Protein Domain Specific Binding (GO:0019904) Transcription Coactivator Activity (GO:0003713) Transcription Corepressor Activity (GO:0003714)

Cross-References

Database	Links
UNIPROT	O35126 P70200 Q80YQ0
Pfam	PF03154

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