NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Calpain-6 - Mus musculus - NucEnvDB

Calpain-6 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Calpain-6
Accession Code	O35646
Gene	Capn6
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 641)
MGPPLKLFKNQKYQELKQECMKDGRLFCDPTFLPENDSLFFNRLLPGKVVWKRPQDISDDPHLIVGNISNHQLIQGRLGNKAMISAFSCLAVQESHWTKAIPNHKDQEWDPRKPEKYAGIFHFRFWHFGE WTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAEIIDMQKGRYTDLVEEKYKLFGELYKTFTKGGLICCSIESPSQEEQEVETDWGLLKGYTYTMTDIR KLRLGERLVEVFSTEKLYMVRLRNPLGRQEWSGPWSEISEEWQQLTVTDRKNLGLVMSDDGEFWMSLEDFCHNFHKLNVCRNVNNPVFGRKELESVVGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFT VPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRRFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGSYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQI TVHSAEGLEKKYANETVNPYLIIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIIQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL

Subcellular Location

Description
Cytoplasm, perinuclear region {By Similarity}. Cytoplasm, cytoskeleton, spindle {Experimental EvidencePubMed:17210638, Experimental EvidencePubMed:20814968}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Microtubule (GO:0005874) Perinuclear Region Of Cytoplasm (GO:0048471) Spindle Microtubule (GO:0005876)

Biology & Function

Description
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues. {Experimental EvidencePubMed:17210638, Experimental EvidencePubMed:21406564}.
Assigned Ontology terms

Biological Process	Microtubule Bundle Formation (GO:0001578) Regulation Of Cytoskeleton Organization (GO:0051493)
Molecular Function	Microtubule Binding (GO:0008017)

Cross-References

Database	Links
UNIPROT	O35646 Q3UM55
Pfam	PF00168 PF01067 PF00648
PROSITE	PS50004 PS50203

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