NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Chitinase-like protein 3 - Mus musculus - NucEnvDB

Chitinase-like protein 3 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Chitinase-like protein 3
Accession Code	O35744
Gene	Chil3
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 398)
MAKLILVTGLAILLNVQLGSSYQLMCYYTSWAKDRPIEGSFKPGNIDPCLCTHLIYAFAGMQNNEITYTHEQDLRDYEAL NGLKDKNTELKTLLAIGGWKFGPAPFSAMVSTPQNRQIFIQSVIRFLRQYNFDGLNLDWQYPGSRGSPPKDKHLFSVLVK EMRKAFEEESVEKDIPRLLLTSTGAGIIDVIKSGYKIPELSQSLDYIQVMTYDLHDPKDGYTGENSPLYKSPYDIGKSAD LNVDSIISYWKDHGAASEKLIVGFPAYGHTFILSDPSKTGIGAPTISTGPPGKYTDESGLLAYYEVCTFLNEGATEVWDA PQEVPYAYQGNEWVGYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGSFCHQRHFPLTSTLKGDLNIHSASCKGPY

Structure Viewer (PDB: 1VF8)

Subcellular Location

Description
Secreted. Rough endoplasmic reticulum lumen. Nucleus envelope. Cytoplasm. Cytoplasmic granule. Note=Predominantly localizes to the lumen of rough endoplasmic reticulum (rER) and nuclear envelope in alveolar macrophages. Localizes to the dilated lumen of rER in immature neutrophils in spleen and in cytoplasmic granules in peritoneal neutrophils. Detected in needle-shaped crystals present in the cytoplasm of bone marrow macrophages.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytoplasmic Vesicle (GO:0031410) Extracellular Region (GO:0005576) Extracellular Space (GO:0005615) Nuclear Envelope (GO:0005635) Rough Endoplasmic Reticulum Lumen (GO:0048237)

Biology & Function

Description
Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy. {Experimental EvidencePubMed:10625674, Experimental EvidencePubMed:11297523, Experimental EvidencePubMed:11733538}.
Assigned Ontology terms

Biological Process	Chitin Catabolic Process (GO:0006032) Inflammatory Response (GO:0006954) Polysaccharide Catabolic Process (GO:0000272) Positive Regulation Of Chemokine Production (GO:0032722) Production Of Molecular Mediator Involved In Inflammatory Response (GO:0002532)
Molecular Function	Beta-N-Acetylhexosaminidase Activity (GO:0004563) Carbohydrate Binding (GO:0030246) Chitin Binding (GO:0008061) Kinase Binding (GO:0019900) N-Acetyl-Beta-D-Galactosaminidase Activity (GO:0102148)

Cross-References

Database	Links
UNIPROT	O35744 P70201 Q3U462 Q3UV87 Q61201
PDB	1E9L 1VF8
Pfam	PF00704
PROSITE	PS51910

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