National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | RNA-directed RNA polymerase p90 |
| Accession Code | O40955 |
| Gene | POLN |
| Organism | Rubella virus vaccine strain RA27/3 (Taxonomy: 11044) |
| Part of Reference Proteome? | No |
| Sequence (Length: 2116) |
Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Host Perinuclear Region | SL-0382 | The host perinuclear region is the host cytoplasmic region just around the host nucleus. Note: This location is defined for viral proteins that appear in the perinuclear region of infected host cells | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
|
|---|---|
| [Non-structural polyprotein p200]: Probable principal replicase for the negative-strand DNA, which replicates the 40S (+) genomic RNA into (-) antigenomic RNA. It cannot replicate the (-) into (+) until cleaved into p150 and p90 mature proteins. {By SimilarityUniProtKB:Q86500}. [Protease/methyltransferase p150]: Protease that cleaves the precursor polyprotein into two mature products. Together with RNA- directed RNA polymerase p90, replicates the 40S genomic and antigenomic RNA by recognizing replications specific signals. The heterodimer P150/p90 is probably the principal replicase for positive-strand genomic RNA and the 24S subgenomic RNA, which codes for structural proteins. Responsible for the mRNA-capping of the viral mRNAs. This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus. Forms fibers late in the infection that may be involved in cell-to-cell spread of the virus RNA in the absence of virus particle formation. {By SimilarityUniProtKB:Q86500}. [RNA-directed RNA polymerase p90]: Together with protease/methyltransferase p150, replicates the 40S genomic and antigenomic RNA by recognizing replications specific signals. The heterodimer P150/p90 is probably the principal replicase for positive- strand genomic RNA and the 24S subgenomic RNA, which codes for structural proteins. A helicase activity is probably also present. {By SimilarityUniProtKB:Q86500}. | Assigned Ontology terms |
Interactions with Nuclear Envelope proteins (1 interactors) |
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|---|---|---|---|
Interactions with other proteins (4 interactors) |
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Database | Links |
| UNIPROT | O40955 |
| Pfam | PF01661 PF05407 PF00978 PF12601 PF01443 |
| PROSITE | PS51743 PS51154 PS51657 PS50507 PS51889 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory