NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Exocyst complex component 8 - Rattus norvegicus - NucEnvDB

Exocyst complex component 8 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Exocyst complex component 8
Accession Code	O54924
Gene	Exoc8
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 716)
MSDSGASRLRRQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRVQALAEETAQNLKRNVYQNYRQFIETAREISYLESEM YQLSHLLTEQKSSLESIPLALLPAAAAGASTGEDTAGAGPRERGAAQAGFLPGPAGVPREGPGTGEEGKQRTLTTLLEKV EGCRDLLETPGQYLVYNGDLVEYEADHMAQLQRVHGFLMNDCLLVATWLPQRRGMYRYNALYPLDRLAVVNVKDNPPMKD MFKLLMFPESRIFQAENAKIKREWLEVLEETKRALSDKRRREQEEAAALRAPPPVTSKGSNPFEDEAEEELATPEAEEEK VDLSMEWIQELPEDLDVCIAQRDFEGAVDLLDKLNHYLEDKPSPPSVKELRAKVDERVRQLTEVLVFELSPDRSLRGGPK ATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKLCHVFFTSLLETAREFETDFAGTDSGCYSAF VVWARSAMGMFVDAFSKQVFDSKESLSTAAECVKVAKEHCQQLGEIGLDLTFIIHALLVKDIQGALLSYKEIIIEATKHR NSEEMWRRMNLMTPEALGKLKEEMRSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHMVLLESLVE VILVAVQHVDYSLRCEQDPEKKTFIRQNASFLYDTVLPVVERRFEEGVGKPAKQLQDLRNASRLLRVNPESTTSVV

Structure Viewer (PDB: 1ZC4)

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:12954101}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:12954101}. Cell projection, growth cone {Experimental EvidencePubMed:12954101}. Cell projection {ECO:0000269\|PubMed:21658605}. Note=Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during NGF-induced neuronal differentiation (PubMed:12954101). Localizes at the leading edge of migrating cells (PubMed:21658605). {ECO:0000250, Experimental EvidencePubMed:12954101, ECO:0000269\|PubMed:21658605}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cell Leading Edge (GO:0031252) Exocyst (GO:0000145) Growth Cone (GO:0030426) Late Endosome (GO:0005770) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Assigned Ontology terms

Biological Process	Endosome Organization (GO:0007032) Exocytosis (GO:0006887) Extracellular Matrix Disassembly (GO:0022617) Golgi To Plasma Membrane Transport (GO:0006893) Protein Localization (GO:0008104) Protein Transport (GO:0015031)
Molecular Function	Phosphatidylinositol Binding (GO:0035091) Small GTPase Binding (GO:0031267)

Cross-References

Database	Links
UNIPROT	O54924
PDB	1ZC3 1ZC4
Pfam	PF16528
PROSITE	PS50003

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