NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

DnaJ homolog subfamily B member 6 - Mus musculus - NucEnvDB

DnaJ homolog subfamily B member 6 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	DnaJ homolog subfamily B member 6
Accession Code	O54946
Gene	Dnajb6
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 365)
MVDYYEVLGVQRHASPEDIKKAYRKQALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGGIHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFEDPFDDFFGNRRGP RGNRSRGAGSFFSTFSGFPSFGSGFPAFDTGFTPFGSLGHGGLTSFSSTSFGGSGMGNFKSISTSTKIVNGKKITTKRIVENGQERVEVEEDGQLKSLTINGVADENALAEECQRRGQPTPALAPGPAPA PVRVPSQARPLAPTPAPTPAPTPAPAPAQTPAPSVSTRPQKPPRPAPTAKLGSKSNWEDDEQDRQRVPGNWDAPMTSAGLKEGGKRKKQKQKEDLKKKKSTKGNH

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:O75190}. Nucleus {By SimilarityUniProtKB:O75190}. Cytoplasm, myofibril, sarcomere, Z line {By SimilarityUniProtKB:O75190}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Z Disc (GO:0030018)

Biology & Function

Description
Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose- dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Actin Cytoskeleton Organization (GO:0030036) Chaperone-Mediated Protein Folding (GO:0061077) Chorio-Allantoic Fusion (GO:0060710) Chorion Development (GO:0060717) Extracellular Matrix Organization (GO:0030198) Intermediate Filament Organization (GO:0045109) Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process (GO:0043154) Negative Regulation Of DNA-Templated Transcription (GO:0045892) Negative Regulation Of Inclusion Body Assembly (GO:0090084) Protein Folding (GO:0006457) Protein Localization To Nucleus (GO:0034504) Regulation Of Protein Localization (GO:0032880) Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development (GO:0060715)
Molecular Function	ATPase Activator Activity (GO:0001671) Chaperone Binding (GO:0051087) DNA Binding (GO:0003677) Heat Shock Protein Binding (GO:0031072) Identical Protein Binding (GO:0042802) Protein Folding Chaperone (GO:0044183) Unfolded Protein Binding (GO:0051082)

Protein-Protein Interactions

Interactions with other proteins (7 interactors)

Partner (UniProt)		IntAct	Confidence score
Q8BWG8	Beta-arrestin-1 (Arrestin beta-1)	EBI-649852	0.37
Q8CG73	Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein)	EBI-4284701	0.35
Q13686	Nucleic acid dioxygenase ALKBH1 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase ALKBH1) (EC 1.14.11.51) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) (EC 1.14.11.33) (mRNA N(3)-methylcytidine demethylase) (EC 1.14.11.-)	EBI-13941029	0.37
P0CB42	Nucleic acid dioxygenase ALKBH1 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase ALKBH1) (EC 1.14.11.51) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) (EC 1.14.11.33) (mRNA N(3)-methylcytidine demethylase) (EC 1.14.11.-) (tRNA N1-methyl adenine demethylase) (EC 1.14.11.-)	EBI-13941082	0.40
P56524	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	EBI-13941106	0.40
Q6P1J9	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)	EBI-20729673	0.35
Q9NRI5	Disrupted in schizophrenia 1 protein	EBI-26612017	0.35

Cross-References

Database	Links
UNIPROT	O54946 Q3TE94 Q3U6L0 Q3UNJ5 Q3UYT7 Q99LA5 Q9QYI9
Pfam	PF00226
PROSITE	PS00636 PS50076

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