NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Argonaute protein wago-4 - Caenorhabditis elegans - NucEnvDB

Argonaute protein wago-4 (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Argonaute protein wago-4
Accession Code	O62275
Gene	wago
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 965)
MPALPPVYTPSGAPSSVHAPPAVPPVPVPTQPLRSEYQTSNDACIKRLEELNIAPAAKLYPTPTEPGKCGVEAEIQTNVFGIEMHQDSLFYQYSVNITTELKNGKEVTFTKKGKDDFVVTERHDKCCAIL FRALGDYEEFFKTSDSCLIYDGQSILFSNVDLFQGFREGAVKTKYMQLDGGEMDHKDLKSLPCIKLEVFPTKNPAVKFTREAVARRATDSNLDSVSLAYQQILELALTQPCLRNTARYVVFDHGKMFFID PLGEGFEKCDVVDVGDGKQVVPGLKKTINFIEGPYGRGRSNPSVVIDGMKVAFHKNQPILDKLKEITTQPVEHGLKGLEKDRCAAVIKGLDCYSTYGGRERHHKIEGIHHEGARNARFELNDGGSCTVAQ YFEDVYNITLRYPDTNLIVSKERGNINFYPMELLKISSHQRVQIPQLTSAQSQKTTKESAVLPDVRQRLILTGKNAAQISSDNEVLGKMGVSVCEDPLMVKGRSIPAVKLANAEIGANPINVKDNKWRAN RFTRPATAPNVWAMYVVGTASTRITLDTLKKFADEFAAMCKSKGVNMPAPADISLIHMDAIESRLYDATKANCTFVFIITDDSITTLHQRYKMIEKDTKMIVQDMKLSKALSVINAGKRLTLENVINKTN VKLGGSNYVFVDAKKQLDSHLIIGVGISAPPAGTKYAMENKGVLNPNVIGYAYNAQHNQEFSGDFVLNSASQDTLAPIEDIVMHSLNEYQKFHDGGLPRRVIVYRTGTSEGNHGSIMAYEIPLARAAMRD FSPDIQLVYIVVSKDHSFRFFKPDLASLASRPQATSSTASRHSAMPAAPKAWDLNIAPGILVDSIVTNPACKQFFLNSHITLQGTAKTPLYTVLADDAKVSMTALEDITYKLCHLHQIVGLPTSLPTPLY VANEYAKRGRNLWNEAVALNNVPTVSGPEADRLKELTKSICYKASGDLTGRRVNA

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:29769721, Experimental EvidencePubMed:29791857, Experimental EvidencePubMed:30728462}. Cytoplasmic granule {Experimental EvidencePubMed:29769721}. Cytoplasm {Experimental EvidencePubMed:29791857}. Note=Co-localizes with znfx-1 in P-granules in germline blastomeres until the 100-cell stage (PubMed:29769721). During oocyte maturation, co-localizes with znfx-1 in liquid-like condensates in the cytoplasm called Z granules (PubMed:29769721). Localizes to cytoplasmic P- granules in germline blastomeres. {Experimental EvidencePubMed:29769721}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway and is required for RNA-mediated gene silencing (RNAi) in the germline (PubMed:17110334, PubMed:29791857, PubMed:30728462). Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue (PubMed:29791857). Also interacts with the mRNA targets of 22G-RNAs (PubMed:29791857). Associates with znfx-1 to mediate small RNA-directed transgenerational epigenetic inheritance of both germline- and soma-expressed genes (PubMed:29791857, PubMed:29769721). {Experimental EvidencePubMed:17110334, Experimental EvidencePubMed:29769721, Experimental EvidencePubMed:29791857, Experimental EvidencePubMed:30728462}.
Assigned Ontology terms

Biological Process	RNA-Mediated Gene Silencing (GO:0031047) RNA-Mediated Heterochromatin Formation (GO:0031048) Regulation Of Gene Silencing By RNA (GO:0060966)
Molecular Function	Endoribonuclease Activity (GO:0004521) MiRNA Binding (GO:0035198) RNA Binding (GO:0003723) Single-Stranded RNA Binding (GO:0003727)

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9XVJ3	Quinoid DihydroPteridine Reductase	EBI-2418620	0.49

Cross-References

Database	Links
UNIPROT	O62275
Pfam	PF02170 PF02171
PROSITE	PS50821 PS50822

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