Protein Information |
|
---|---|
Protein Name | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Accession Code | O70628 |
Gene | Pde9a |
Organism | Mus musculus | House mouse (Taxonomy: 10090) |
Part of Reference Proteome? | Yes |
Sequence (Length: 534) |
Description |
Position in the Nuclear Envelope |
|
---|---|---|
Location | Location ID | Description |
Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
Topology | Source | Annotation Type |
Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
|
---|---|
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:9624145). Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide- dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide- dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic- peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (PubMed:22328573, PubMed:24746365). {Experimental EvidencePubMed:22328573, Experimental EvidencePubMed:24746365, Experimental EvidencePubMed:25799991, Experimental EvidencePubMed:9624145, Curator Inference}. | Assigned Ontology terms |