National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Cryptochrome-1 |
| Accession Code | O77059 |
| Gene | cry |
| Organism | Drosophila melanogaster (Taxonomy: 7227) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 542) |
Structure Viewer (PDB: 4GU5) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing. {Experimental EvidencePubMed:10063806, Experimental EvidencePubMed:10233998, Experimental EvidencePubMed:10417378, Experimental EvidencePubMed:16527739, Experimental EvidencePubMed:17298948, Experimental EvidencePubMed:18597555, Experimental EvidencePubMed:18641630, Experimental EvidencePubMed:9845369, Experimental EvidencePubMed:9845370}. | Assigned Ontology terms |
Interactions with Nuclear Envelope proteins (2 interactors) |
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Interactions with other proteins (1 interactors) |
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Database | Links |
| UNIPROT | O77059 Q9TYA0 |
| PDB | 4GU5 4JZY 4K03 6WTB |
| Pfam | PF00875 PF03441 |
| PROSITE | PS51645 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory