National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | Serine/threonine-protein kinase 16 |
| Accession Code | O88697 |
| Gene | Stk16 |
| Organism | Mus musculus | House mouse (Taxonomy: 10090) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 305) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Lipid-Anchored | UniProt | By Similarity {ECO:0000250} | Assigned Ontology terms |
Description |
|
|---|---|
| Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. {By Similarity, Experimental EvidencePubMed:9878782}. | Assigned Ontology terms |
Database | Links |
| UNIPROT | O88697 Q3UEG5 Q9JMJ0 Q9JMJ1 Q9QX00 |
| Pfam | PF00069 |
| PROSITE | PS50011 PS00108 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory