NucEnvDB
NucEnvDB
A database of Nuclear Envelope Proteins and their Interactions
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Amyloid-beta A4 precursor protein-binding family A member 3 - Mus musculus - NucEnvDB
Amyloid-beta A4 precursor protein-binding family A member 3 (
Mus musculus
)
FASTA
TEXT
XML
Subcellular Location
Biology & Function
Interactions
Cross-References
General Information
Protein Information
Protein Name
Amyloid-beta A4 precursor protein-binding family A member 3
Accession Code
O88888
Gene
Apba3
Organism
Mus musculus
| House mouse (Taxonomy:
10090
)
Part of Reference Proteome?
Yes
Sequence (Length: 571)
Show
MEFLPGPQHPPGPPTMDLEEPKGPEVPSENHPSNTQSALGPGGPVTLSEMELDTSSVQELVQQLEALPSDLGGPFPDGAPCPLHIATGQGLATQENPDAGGLLSAEAGGDDLLGLLRDEASSPAQSVPQD
PAQTAPRLLQPPEDPDGDPGWMEGASAEPADSRSSSSSPEPWLETAPLVTQQEPPVGTQSRETLASCPAVTEVPGPCGPEELMDGVIFGAKYLGSTQLLSERSPAPSTRMGQAQEAMDRVKAPEGETQPM
VEVDIFISTKRVKVLAADSQDALMDHALQTISYIADIGPVLVLMARRRLARRTTPQDRQRRLYKMLCHVFHSEDAQLIAQAIGQAFSIAYSQFLQENRIDPSQVGTQPSTAASHPHNGDLDHFCNSQNCR
EVCIQKRPGEGLGVALVESGWGSLLPTAVIANLLHGGPAERCGALSIGDRVTAINGTSLVGLSLAACQAAVREVRRLSSVTLSIIHCPPVTTAVIRRPHVREQLGFCVEDGIICSLLRGGAAERGGVRVG
HRIIEVNGQSVVAMPHARIIQLLTETREIHIKTMPAATYRLLTGQEQPVYL
Subcellular Location
Description
Show
Cytoplasm, perinuclear region {
By Similarity
}.
Position in the Nuclear Envelope
Location
Location ID
Description
Perinuclear Region
SL-0198
The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology
Source
Annotation Type
Unknown
UniProt
Sequence Analysis
Assigned Ontology terms
Show
Cellular Component
Cytoplasm
(
GO:0005737
)
Dendritic Spine
(
GO:0043197
)
Perinuclear Region Of Cytoplasm
(
GO:0048471
)
Plasma Membrane
(
GO:0005886
)
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Biology & Function
Description
Hide
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity). {
By Similarity
}.
Assigned Ontology terms
Show
Biological Process
Chemical Synaptic Transmission
(
GO:0007268
)
In Utero Embryonic Development
(
GO:0001701
)
Negative Regulation Of Catalytic Activity
(
GO:0043086
)
Protein Transport
(
GO:0015031
)
Regulation Of Gene Expression
(
GO:0010468
)
Molecular Function
Amyloid-Beta Binding
(
GO:0001540
)
Enzyme Binding
(
GO:0019899
)
Enzyme Inhibitor Activity
(
GO:0004857
)
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Protein-Protein Interactions
Interactions with Nuclear Envelope proteins (1 interactors)
Show
Partner (NucEnvDB)
IntAct
Confidence score
P0C6X9
2'-O-methyltransferase
EBI-25509102
0.37
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Cross-References
Database
Links
UNIPROT
O88888
Q3TDI1
Q8BR09
Pfam
PF00595
PF00640
PROSITE
PS50106
PS01179
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory