National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Deoxyribonuclease-1 |
| Accession Code | P00639 |
| Gene | DNASE1 |
| Organism | Bos taurus | Cattle (Taxonomy: 9913) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 282) |
Structure Viewer (PDB: 2A3Z) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:4976790, PubMed:5166750, PubMed:3352748, PubMed:2395459). Expressed by non- hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:2395459). Binds specifically to G-actin and blocks actin polymerization (PubMed:2395459). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). {By SimilarityUniProtKB:P21704, By SimilarityUniProtKB:P49183, Experimental EvidencePubMed:2395459, Experimental EvidencePubMed:3352748, Experimental EvidencePubMed:4976790, Experimental EvidencePubMed:5166750}. | Assigned Ontology terms |
Interactions with other proteins (3 interactors) |
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|---|---|---|---|
Database | Links |
| UNIPROT | P00639 A5PK44 Q8MJ27 |
| PDB | 1ATN 1DNK 2A3Z 2A40 2A41 2A42 2D1K 2DNJ 3CJC 3DNI 3W3D 7NXV 7NZM |
| Pfam | PF03372 |
| PROSITE | PS00919 PS00918 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory